| http://purl.uniprot.org/citations/21123580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21123580 | http://www.w3.org/2000/01/rdf-schema#comment | "N-Cadherin has an important role during dendrite arborization, axon guidance, and synaptogenesis. In particular, at synaptic sites, N-cadherin is involved in the regulation of cell-cell adhesion and in morphology and plasticity control. Recent studies have shown that N-cadherin can be cleaved by the metalloproteinase ADAM10. Here we demonstrate that impairing ADAM10 localization and activity at synaptic sites decreases its processing of N-cadherin. This leads to an accumulation of the full-length form of N-cadherin, to an increase in spine head width, and to modifications of the number and function of glutamate receptors of AMPA type, both in vitro and in vivo. Our results indicate a key role for ADAM10 in the complex sequence of events through which N-cadherin affects spine maturation and controls structure and function of glutamatergic synapses."xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.1984-10.2010"xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/author | "Mulle C."xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/author | "Sala C."xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/author | "Di Luca M."xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/author | "Gardoni F."xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/author | "Marcello E."xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/author | "Carta M."xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/author | "Cattabeni F."xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/author | "Verpelli C."xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/author | "Epis R."xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/author | "Malinverno M."xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/pages | "16343-16355"xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/title | "Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage."xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/21123580 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21123580 |
| http://purl.uniprot.org/citations/21123580 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21123580 |
| http://purl.uniprot.org/uniprot/O35598#attribution-D6ED426EEA04BB72D1FF9B1C227B20C3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21123580 |
| http://purl.uniprot.org/uniprot/#_D3Z1E6-mappedCitation-21123580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21123580 |
| http://purl.uniprot.org/uniprot/#_A0AV88-mappedCitation-21123580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21123580 |
| http://purl.uniprot.org/uniprot/#_O14672-mappedCitation-21123580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21123580 |
| http://purl.uniprot.org/uniprot/#_O35598-mappedCitation-21123580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21123580 |