| http://purl.uniprot.org/citations/21124968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21124968 | http://www.w3.org/2000/01/rdf-schema#comment | "Metallothioneins (MTs) are small, cysteine-rich polypeptides, but the role of MTs in inducing the formation of adaptive response is still largely unknown. We investigated the roles of metallothionein genes (mtl-1 and mtl-2) in the formation of cross-adaptation response to neurobehavioral toxicity from metal exposure in Caenorhabditis elegans. Pre-treatment with mild heat-shock at L2-larva stage effectively prevented the formation of the neurobehavioral defects and the activation of severe stress response in metal exposed nematodes at concentrations of 50 and 100 µM, but pre-treatment with mild heat-shock did not prevent the formation of neurobehavioral defects in 200 µM of metal exposed nematodes. During the formation of cross-adaptation response, the induction of mtl-1 and mtl-2 promoter activity and subsequent GFP gene expression were sharply increased in 50 µM or 100 µM of metal exposed Pmtl-1::GFP and Pmtl-2::GFP transgenic adult animals after mild heat-shock treatment compared with those treated with mild heat-shock or metal exposure alone. Moreover, after pre-treatment with mild heat-shock, no noticeable increase of locomotion behaviors could be observed in metal exposed mtl-1 or mtl-2 mutant nematodes compared to those without mild heat-shock pre-treatment. The defects of adaptive response to neurobehavioral toxicity induced by metal exposure formed in mtl-1 and mtl-2 mutants could be completely rescued by the expression of mtl-1 and mtl-2 with the aid of their native promoters. Furthermore, over-expression of MTL-1 and MTL-2 at the L2-larval stage significantly suppressed the toxicity on locomotion behaviors from metal exposure at all examined concentrations. Therefore, the normal formation of cross-adaptation response to neurobehavioral toxicity induced by metal exposure may need the enough accumulation of MTs protein in animal tissues."xsd:string |
| http://purl.uniprot.org/citations/21124968 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0014052"xsd:string |
| http://purl.uniprot.org/citations/21124968 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/21124968 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/21124968 | http://purl.uniprot.org/core/author | "Ye B."xsd:string |
| http://purl.uniprot.org/citations/21124968 | http://purl.uniprot.org/core/author | "Rui Q."xsd:string |
| http://purl.uniprot.org/citations/21124968 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21124968 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21124968 | http://purl.uniprot.org/core/pages | "e14052"xsd:string |
| http://purl.uniprot.org/citations/21124968 | http://purl.uniprot.org/core/title | "Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes."xsd:string |
| http://purl.uniprot.org/citations/21124968 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/21124968 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21124968 |
| http://purl.uniprot.org/citations/21124968 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21124968 |
| http://purl.uniprot.org/uniprot/P17511#attribution-F97DEF30A3D95C8466D1ADDCA905B086 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21124968 |
| http://purl.uniprot.org/uniprot/#_P17511-mappedCitation-21124968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21124968 |
| http://purl.uniprot.org/uniprot/#_P17512-mappedCitation-21124968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21124968 |
| http://purl.uniprot.org/uniprot/P17511 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21124968 |
| http://purl.uniprot.org/uniprot/P17512 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21124968 |