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Objective

To explore the interaction between BCL2-associated athanogene 5 (BAG5) and Parkin protein,and the regulatory mechanism of BAG5 protein on the level of Parkin protein.

Methods

We performed GST pull-down assay to identify which domain of PINK1 interacted with Parkin, and generated different deletions of BAG5 to identify the domains. Chase time experiment was done to determine the effect of co-regulation of BAG5 protein on the ubiquitination. We further examined the possible interaction between Parkin and PINK1 in 293A cells by co-immunoprecipitation method.

Results

BAG5 directly interacted with the Parkin, and all the 4 BAG domains interacted with the Parkin. BAG5 stabilized the Parkin by interfering its degradation via the ubiquitin-mediated proteasomal pathway.

Conclusion

BAG5 directly interacts with the Parkin, and BAG5 stabilizes the Parkin via the ubiquitin-mediated proteasomal pathway."xsd:string
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http://purl.uniprot.org/citations/21131737http://purl.uniprot.org/core/author"Guo J."xsd:string
http://purl.uniprot.org/citations/21131737http://purl.uniprot.org/core/author"Jiang H."xsd:string
http://purl.uniprot.org/citations/21131737http://purl.uniprot.org/core/author"Shen L."xsd:string
http://purl.uniprot.org/citations/21131737http://purl.uniprot.org/core/author"Tang B."xsd:string
http://purl.uniprot.org/citations/21131737http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/21131737http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/21131737http://purl.uniprot.org/core/name"Zhong Nan Da Xue Xue Bao Yi Xue Ban"xsd:string
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http://purl.uniprot.org/citations/21131737http://purl.uniprot.org/core/title"[Direct interaction between BAG5 protein and Parkin protein]."xsd:string
http://purl.uniprot.org/citations/21131737http://purl.uniprot.org/core/volume"35"xsd:string
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