| http://purl.uniprot.org/citations/21132009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21132009 | http://www.w3.org/2000/01/rdf-schema#comment | "Human clear cell renal cell carcinoma (CCC) remains resistant to therapies. The transcription factor LIM-class homeobox gene Lim1 is required for normal organogenesis, including nephrogenesis, by regulating cell movements, differentiation and growth. Its expression is controlled partly by the sonic hedgehog-Gli signaling pathway, which we have recently shown to be reactivated in human CCC. So far, no study has assessed whether Lim1 may be associated with tumorigenesis. Using a panel of human CCC cell lines expressing or not the von Hippel-Lindau tumor suppressor gene and 44 tumor/normal tissues pairs, we found that Lim1 is constitutively and exclusively reexpressed in tumors. Through Lim1 silencing or overexpressing, we show that Lim1 is a growth and survival factor in human CCC, at least through the activation of oncogenic pathways including the phosphoinositide kinase-3/Akt and nuclear factor-kappaB pathways. More importantly, in nude mice bearing human CCC tumors, Lim1 silencing abolished tumor growth through the same mechanism as in vitro. In Lim1-depleted cells and tumors, cell movements were substantially impaired because of the inhibition of expression of various proteins involved in metastatic spread, such as paxillin or tenascin-C. These findings establish that the developmental marker Lim1 acts as an oncogene in cancer cells and targeting Lim1 may constitute an innovative therapeutic intervention in human CCC."xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2010.557"xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/author | "Lang H."xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/author | "Thomas L."xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/author | "Beraud C."xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/author | "Lindner V."xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/author | "Barthelmebs M."xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/author | "Coquard C."xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/author | "Jacqmin D."xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/author | "Massfelder T."xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/author | "Dormoy V."xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/pages | "1753-1763"xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/title | "LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma."xsd:string |
| http://purl.uniprot.org/citations/21132009 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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