| http://purl.uniprot.org/citations/21132015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21132015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21132015 | http://www.w3.org/2000/01/rdf-schema#comment | "The receptor protein tyrosine kinase 7 (PTK7) was recently shown to participate in noncanonical Wnt/planar cell polarity signalling during mouse and frog embryonic development. In this study, we report that PTK7 interacts with β-catenin in a yeast two-hybrid assay and mammalian cells. PTK7-deficient cells exhibit weakened β-catenin/T-cell factor transcriptional activity on Wnt3a stimulation. Furthermore, Xenopus PTK7 is required for the formation of Spemann's organizer and for Siamois promoter activation, events that require β-catenin transcriptional activity. Using epistatic assays, we demonstrate that PTK7 functions upstream from glycogen synthase kinase 3. Taken together, our data reveal a new and conserved role for PTK7 in the Wnt canonical signalling pathway."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2010.185"xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2010.185"xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Lee S.T."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Borg J.-P."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Borg J.-P."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Borg J.P."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Lecine P."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Lecine P."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Marchetto S."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Marchetto S."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Sebbagh M."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Sebbagh M."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Prebet T."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Prebet T."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Lembo F."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Lembo F."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Kodjabachian L."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Kodjabachian L."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Thome V."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Thome V."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Gangar A."xsd:string |
| http://purl.uniprot.org/citations/21132015 | http://purl.uniprot.org/core/author | "Gangar A."xsd:string |