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http://purl.uniprot.org/citations/21134747http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21134747http://www.w3.org/2000/01/rdf-schema#comment"Herein we describe the synthesis and structure activity relationship of a new class of FXR agonists identified from a high-throughput screening campaign. Further optimization of the original hits led to molecules that were highly active in an LDL-receptor KO model for dyslipidemia. The most promising candidate is discussed in more detail."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.org/dc/terms/identifier"doi:10.1016/j.bmcl.2010.11.039"xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Feng S."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Taylor S."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Rudolph M.G."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Martin R.E."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Kuhn B."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Blum D."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Grether U."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Gardes C."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Schuler F."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Richter H.G."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Chaput E."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Benson G.M."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Hartman P."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Plancher J.M."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/author"Bleicher K.H."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/name"Bioorg Med Chem Lett"xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/pages"191-194"xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/title"Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes."xsd:string
http://purl.uniprot.org/citations/21134747http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/21134747http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21134747
http://purl.uniprot.org/citations/21134747http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21134747