| http://purl.uniprot.org/citations/21135091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21135091 | http://www.w3.org/2000/01/rdf-schema#comment | "Vesicular transport shuttles cargo among intracellular compartments. Several stages of vesicular transport are mediated by the small GTPase Arf, which is controlled in a cycle of GTP binding and hydrolysis by Arf guanine-nucleotide exchange factors and Arf GTPase-activating proteins (ArfGAPs), respectively. In budding yeast the Age2 + Gcs1 ArfGAP pair facilitates post-Golgi transport. We have found the AGE1 gene, encoding another ArfGAP, can in high gene-copy number alleviate the temperature sensitivity of cells carrying mutations affecting the Age2 + Gcs1 ArfGAP pair. Moreover, increased AGE1 gene dosage compensates for the complete absence of the otherwise essential Age2 + Gcs1 ArfGAP pair. Increased dosage of SFH2, encoding a phosphatidylinositol transfer protein, also allows cell growth in the absence of the Age2 + Gcs1 pair, but good growth in this situation requires Age1. The ability of Age1 to overcome the need for Age2 + Gcs1 depends on phospholipase D activity that regulates lipid composition. We show by direct assessment of Age1 ArfGAP activity that Age1 is regulated by lipid composition and can provide ArfGAP function for post-Golgi transport."xsd:string |
| http://purl.uniprot.org/citations/21135091 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.185108"xsd:string |
| http://purl.uniprot.org/citations/21135091 | http://purl.uniprot.org/core/author | "Lewis S.M."xsd:string |
| http://purl.uniprot.org/citations/21135091 | http://purl.uniprot.org/core/author | "Auger A."xsd:string |
| http://purl.uniprot.org/citations/21135091 | http://purl.uniprot.org/core/author | "Johnston G.C."xsd:string |
| http://purl.uniprot.org/citations/21135091 | http://purl.uniprot.org/core/author | "Poon P.P."xsd:string |
| http://purl.uniprot.org/citations/21135091 | http://purl.uniprot.org/core/author | "Singer R.A."xsd:string |
| http://purl.uniprot.org/citations/21135091 | http://purl.uniprot.org/core/author | "Wong T.A."xsd:string |
| http://purl.uniprot.org/citations/21135091 | http://purl.uniprot.org/core/author | "Benjamin J.J."xsd:string |
| http://purl.uniprot.org/citations/21135091 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21135091 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21135091 | http://purl.uniprot.org/core/pages | "5187-5196"xsd:string |
| http://purl.uniprot.org/citations/21135091 | http://purl.uniprot.org/core/title | "The yeast Arf GTPase-activating protein Age1 is regulated by phospholipase D for post-Golgi vesicular transport."xsd:string |
| http://purl.uniprot.org/citations/21135091 | http://purl.uniprot.org/core/volume | "286"xsd:string |
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