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| http://purl.uniprot.org/citations/21135140 | http://www.w3.org/2000/01/rdf-schema#comment | "Binding of ligands by immunoreceptors is thought to be a passive, stochastic process. Contrary to this notion, we found that binding of IgG-opsonized particles by Fcγ receptors was inhibited in macrophages, dendritic and microglial cells by agents that interfere with actin assembly or disassembly. Changes in the lateral mobility of the receptors--assessed by single-particle tracking--or in the microelasticity of the membrane--determined by atomic-force microscopy--could not account for the effects of actin disruption on particle binding. Instead, we found that the macrophages contact their targets by actively extending actin-rich structures. Formation of these protrusions is driven by Rac and requires phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Capture of C3bi-opsonized as well as unopsonized targets by macrophages was also dependent on actin. Thus, phagocytes continuously probe their environment for foreign particles in a manner akin to the constitutive sampling of the fluid milieu by dendritic cells. Active probing by phagocytes is most important when confronted by scarcely opsonized and/or highly mobile targets."xsd:string |
| http://purl.uniprot.org/citations/21135140 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201007056"xsd:string |
| http://purl.uniprot.org/citations/21135140 | http://purl.uniprot.org/core/author | "Grinstein S."xsd:string |
| http://purl.uniprot.org/citations/21135140 | http://purl.uniprot.org/core/author | "Harrison R.E."xsd:string |
| http://purl.uniprot.org/citations/21135140 | http://purl.uniprot.org/core/author | "Flannagan R.S."xsd:string |
| http://purl.uniprot.org/citations/21135140 | http://purl.uniprot.org/core/author | "Yip C.M."xsd:string |
| http://purl.uniprot.org/citations/21135140 | http://purl.uniprot.org/core/author | "Jaqaman K."xsd:string |
| http://purl.uniprot.org/citations/21135140 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21135140 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/21135140 | http://purl.uniprot.org/core/pages | "1205-1218"xsd:string |
| http://purl.uniprot.org/citations/21135140 | http://purl.uniprot.org/core/title | "Dynamic macrophage "probing" is required for the efficient capture of phagocytic targets."xsd:string |
| http://purl.uniprot.org/citations/21135140 | http://purl.uniprot.org/core/volume | "191"xsd:string |
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