| http://purl.uniprot.org/citations/21135237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21135237 | http://www.w3.org/2000/01/rdf-schema#comment | "The accumulation of AMPA receptors (AMPARs) at synapses is essential for excitatory synaptic transmission. However, the mechanisms underlying synaptic targeting of AMPARs remain elusive. We have now used a molecular replacement approach on an AMPAR-null background to investigate the targeting mechanisms necessary for regulating AMPAR trafficking in the hippocampus. Although there is an extensive literature on the role of the GluA1 C-tail in AMPAR trafficking, there is no effect of overexpressing the C-tail on basal transmission. Instead, we found that the first intracellular loop domain (Loop1) of GluA1, a previously overlooked region within AMPARs, is critical for receptor targeting to synapses, but not for delivery of receptors to the plasma membrane. We also identified a CaMKII phosphorylation site (S567) in the GluA1 Loop1, which is phosphorylated in vitro and in vivo. Furthermore, we show that S567 is a key residue that regulates Loop1-mediated AMPAR trafficking. Thus, our study reveals a unique mechanism for targeting AMPARs to synapses to mediate synaptic transmission."xsd:string |
| http://purl.uniprot.org/citations/21135237 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1016289107"xsd:string |
| http://purl.uniprot.org/citations/21135237 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/21135237 | http://purl.uniprot.org/core/author | "Nicoll R.A."xsd:string |
| http://purl.uniprot.org/citations/21135237 | http://purl.uniprot.org/core/author | "Roche K.W."xsd:string |
| http://purl.uniprot.org/citations/21135237 | http://purl.uniprot.org/core/author | "Isozaki K."xsd:string |
| http://purl.uniprot.org/citations/21135237 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21135237 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21135237 | http://purl.uniprot.org/core/pages | "22266-22271"xsd:string |
| http://purl.uniprot.org/citations/21135237 | http://purl.uniprot.org/core/title | "Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1."xsd:string |
| http://purl.uniprot.org/citations/21135237 | http://purl.uniprot.org/core/volume | "107"xsd:string |
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