| http://purl.uniprot.org/citations/21139332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21139332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21139332 | http://www.w3.org/2000/01/rdf-schema#comment | "Ribosomal protein L3 (RPL3) is known to be an indispensable and essential component for the peptidyltransferase center. In the present study, we found a novel function of RPL3 using a Xenopus laevis oocyte expression system. When expressed in X. oocytes, RPL3 mediated the high affinity transport of [(3)H]digoxin (K(m) = 213.3 ± 46.8 nM) in a time-, concentration-, and sodium-dependent manners. The maximum velocity of the transport of [(3)H]digoxin via RPL3 produced at physiological pH. However, we did not observe RPL3-mediated transport of several organic solutes such as [(14)C]androstenedione, [(3)H]dexamethasone, [(3)H]dehydroepiandrosterone sulfate, [(3)H]L-tryptophan, [(14)C]L-ascorbic acid, [(14)C]α-ketoglutarate, [(14)C]glutarate, [(3)H]methotrexate, [(3)H]bumetanide, [(3)H]probenecid, [(14)C]salicylic acid, [(14)C]theophylline and [(3)H]valproate. Our results suggest that RPL3 functions as a drug carrier protein and may be involved in the digoxin toxicity in the human body."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.org/dc/terms/identifier | "doi:10.2131/jts.35.827"xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.org/dc/terms/identifier | "doi:10.2131/jts.35.827"xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/author | "Ohbayashi M."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/author | "Ohbayashi M."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/author | "Kawakami K."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/author | "Kawakami K."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/author | "Kohyama N."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/author | "Kohyama N."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/name | "J. Toxicol. Sci."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/name | "J Toxicol Sci"xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/pages | "827-834"xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/pages | "827-834"xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/title | "Ribosomal protein L3 mediated the transport of digoxin in Xenopus laevis oocyte."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/title | "Ribosomal protein L3 mediated the transport of digoxin in Xenopus laevis oocyte."xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/21139332 | http://purl.uniprot.org/core/volume | "35"xsd:string |