| http://purl.uniprot.org/citations/21145506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21145506 | http://www.w3.org/2000/01/rdf-schema#comment | "Centrioles form cilia and centrosomes, organelles whose dysfunction is increasingly linked to human disease. Centriole duplication relies on a few conserved proteins (ZYG-1/Sak/Plk4, SAS-6, SAS-5/Ana2, and SAS-4), and is often initiated by the formation of an inner "cartwheel" structure. Here, we show that overexpressed Drosophila Sas-6 and Ana2 coassemble into extended tubules (SAStubules) that bear a striking structural resemblance to the inner cartwheel of the centriole. SAStubules specifically interact with centriole proximal ends, but extra DSas-6/Ana2 is only recruited onto centrioles when Sak/Plk4 kinase is also overexpressed. This extra centriolar DSas-6/Ana2 induces centriole overduplication and, surprisingly, increased centriole cohesion. Intriguingly, we observe tubules that are structurally similar to SAStubules linking the engaged centrioles in normal wild-type cells. We conclude that DSas-6 and Ana2 normally cooperate to drive the formation of the centriole inner cartwheel and that they promote both centriole duplication and centriole cohesion in a Sak/Plk4-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/21145506 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2010.11.010"xsd:string |
| http://purl.uniprot.org/citations/21145506 | http://purl.uniprot.org/core/author | "Raff J.W."xsd:string |
| http://purl.uniprot.org/citations/21145506 | http://purl.uniprot.org/core/author | "Roque H."xsd:string |
| http://purl.uniprot.org/citations/21145506 | http://purl.uniprot.org/core/author | "Stevens N.R."xsd:string |
| http://purl.uniprot.org/citations/21145506 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21145506 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/21145506 | http://purl.uniprot.org/core/pages | "913-919"xsd:string |
| http://purl.uniprot.org/citations/21145506 | http://purl.uniprot.org/core/title | "DSas-6 and Ana2 coassemble into tubules to promote centriole duplication and engagement."xsd:string |
| http://purl.uniprot.org/citations/21145506 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/21145506 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21145506 |
| http://purl.uniprot.org/citations/21145506 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21145506 |
| http://purl.uniprot.org/uniprot/O97143#attribution-2344F137BEC719B411545B1A11D5B3A3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21145506 |
| http://purl.uniprot.org/uniprot/Q9VAC8#attribution-2344F137BEC719B411545B1A11D5B3A3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21145506 |
| http://purl.uniprot.org/uniprot/Q9VNE4#attribution-2344F137BEC719B411545B1A11D5B3A3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21145506 |
| http://purl.uniprot.org/uniprot/Q9XZ31#attribution-2344F137BEC719B411545B1A11D5B3A3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21145506 |
| http://purl.uniprot.org/uniprot/Q9VI72#attribution-2344F137BEC719B411545B1A11D5B3A3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21145506 |
| http://purl.uniprot.org/uniprot/A0A0B4LFU9#attribution-2344F137BEC719B411545B1A11D5B3A3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21145506 |
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| http://purl.uniprot.org/uniprot/#_O97143-mappedCitation-21145506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21145506 |
| http://purl.uniprot.org/uniprot/#_Q9VAC8-mappedCitation-21145506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21145506 |
| http://purl.uniprot.org/uniprot/#_Q9XZ31-mappedCitation-21145506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21145506 |
| http://purl.uniprot.org/uniprot/#_Q9VNE4-mappedCitation-21145506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21145506 |
| http://purl.uniprot.org/uniprot/#_Q9VI72-mappedCitation-21145506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21145506 |