| http://purl.uniprot.org/citations/21145879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21145879 | http://www.w3.org/2000/01/rdf-schema#comment | "Equilibrative nucleoside transporters (ENTs) are facilitative transporters broadly selective for pyrimidine and purine nucleosides and are essential for the modulation of nucleoside concentration and nucleoside analog availability. Resistance to nucleoside-derived drugs strongly correlates with a deficiency of ENT1 expression in several tumor cells. Thus, it is crucial to understand the mechanisms by which this transporter is modulated. Using a mouse myeloid leukemic cell line as a model, we investigated whether stress-activated kinases regulate ENT1 expression and function. JNK activation, but not p38 MAPK results in rapid loss of mENT1 function, mRNA expression and promoter activity. c-Jun but not the mutant c-Jun Ser63/73Ala, decreased mENT1 promoter activity. Moreover cJun bound to an AP-1 site identified at -1196 of the promoter, suggesting a specific role for this transcription factor in mENT1 regulation. We propose that activation of JNK-cJun pathway negatively regulates mENT1 and suggest that this mechanism might contribute to the development of nucleoside analog-derived drug resistance."xsd:string |
| http://purl.uniprot.org/citations/21145879 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.11.125"xsd:string |
| http://purl.uniprot.org/citations/21145879 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/21145879 | http://purl.uniprot.org/core/author | "Huang M."xsd:string |
| http://purl.uniprot.org/citations/21145879 | http://purl.uniprot.org/core/author | "Graves L.M."xsd:string |
| http://purl.uniprot.org/citations/21145879 | http://purl.uniprot.org/core/author | "Leisewitz A.V."xsd:string |
| http://purl.uniprot.org/citations/21145879 | http://purl.uniprot.org/core/author | "Zimmerman E.I."xsd:string |
| http://purl.uniprot.org/citations/21145879 | http://purl.uniprot.org/core/author | "Jones S.Z."xsd:string |
| http://purl.uniprot.org/citations/21145879 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21145879 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/21145879 | http://purl.uniprot.org/core/pages | "370-375"xsd:string |
| http://purl.uniprot.org/citations/21145879 | http://purl.uniprot.org/core/title | "Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase."xsd:string |
| http://purl.uniprot.org/citations/21145879 | http://purl.uniprot.org/core/volume | "404"xsd:string |
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