| http://purl.uniprot.org/citations/21148555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21148555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21148555 | http://www.w3.org/2000/01/rdf-schema#comment | "The phospholipids of Escherichia coli consist mainly of phosphatidylethanolamine, phosphatidylglycerol (PG), and cardiolipin. PG makes up ∼25% of the cellular phospholipid and is essential for growth in wild-type cells. PG is synthesized on the inner surface of the inner membrane from cytidine diphosphate-diacylglycerol and glycerol 3-phosphate, generating the precursor phosphatidylglycerol-phosphate (PGP). This compound is present at low levels (∼0.1% of the total lipid). Dephosphorylation of PGP to PG is catalyzed by several PGP-phosphatases. The pgpA and pgpB genes, which encode structurally distinct PGP-phosphatases, were identified previously. Double deletion mutants lacking pgpA and pgpB are viable and still make PG, suggesting the presence of additional phosphatase(s). We have identified a third PGP-phosphatase gene (previously annotated as yfhB but renamed pgpC) using an expression cloning strategy. A mutant with deletions in all three phosphatase genes is not viable unless covered by a plasmid expressing either pgpA, pgpB, or pgpC. When the triple mutant is covered with the temperature-sensitive plasmid pMAK705 expressing any one of the three pgp genes, the cells grow at 30 but not 42 °C. As growth slows at 42 °C, PGP accumulates to high levels, and the PG content declines. PgpC orthologs are present in many other bacteria."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.199265"xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.199265"xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/author | "Guan Z."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/author | "Guan Z."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/author | "Lu Y.H."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/author | "Lu Y.H."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/author | "Raetz C.R."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/author | "Raetz C.R."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/pages | "5506-5518"xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/pages | "5506-5518"xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/title | "Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/title | "Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli."xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21148555 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21148555 |
| http://purl.uniprot.org/citations/21148555 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21148555 |