| http://purl.uniprot.org/citations/21148742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21148742 | http://www.w3.org/2000/01/rdf-schema#comment | "The murine surfactant-associated protein B (Sftpb) gene promoter, spanning nucleotides -653 to +42, is composed of functionally distinct proximal and distal regions. Although both regions contain consensus/putative activator protein 1 (AP-1) sites, the distal, but not the proximal, region mediates the inhibition by jun proto-oncogene (JUN) of Sftpb promoter activity. In transient cotransfection assays, JUN inhibited the luciferase reporter activity of plasmid constructs containing Sftpb promoter fragments that lacked the distal putative AP-1 site, indicating that another regulatory motif mediates JUN-dependent inhibition. Electrophoretic mobility shift assays and in silico analyses identified a DNA target sequence (Sftpb nucleotides -339 to -316) and transcription factors that regulate Sftpb promoter activity. The identified sequence contains a CCAAT/enhancer-binding protein (C/EBP) consensus recognition element. Mutation of the site reduced Sftpb promoter activity and sensitivity to inhibition by JUN. Purified recombinant JUN, which did not recognize the -339 to -316 target sequence when added alone, supershifted the mobility of in vitro translated C/EBP-α and C/EBP-β proteins complexed with the identified cis-regulatory element. These findings support the idea that heterodimerization between JUN and C/EBP-α and/or C/EBP-β targets JUN to the Sftpb promoter, thereby mediating its inhibitory regulatory role."xsd:string |
| http://purl.uniprot.org/citations/21148742 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2010-0260oc"xsd:string |
| http://purl.uniprot.org/citations/21148742 | http://purl.uniprot.org/core/author | "Bein K."xsd:string |
| http://purl.uniprot.org/citations/21148742 | http://purl.uniprot.org/core/author | "Leikauf G.D."xsd:string |
| http://purl.uniprot.org/citations/21148742 | http://purl.uniprot.org/core/author | "Leight H."xsd:string |
| http://purl.uniprot.org/citations/21148742 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21148742 | http://purl.uniprot.org/core/name | "Am J Respir Cell Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/21148742 | http://purl.uniprot.org/core/pages | "436-444"xsd:string |
| http://purl.uniprot.org/citations/21148742 | http://purl.uniprot.org/core/title | "JUN-CCAAT/enhancer-binding protein complexes inhibit surfactant-associated protein B promoter activity."xsd:string |
| http://purl.uniprot.org/citations/21148742 | http://purl.uniprot.org/core/volume | "45"xsd:string |
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