| http://purl.uniprot.org/citations/21149441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21149441 | http://www.w3.org/2000/01/rdf-schema#comment | "Protease-activated receptor (PAR) signaling is closely linked to the cellular activation of the pro- and anticoagulant pathways. The endothelial protein C receptor (EPCR) is crucial for signaling by activated protein C through PAR1, but EPCR may have additional roles by interacting with the 4-carboxyglutamic acid domains of procoagulant coagulation factors VII (FVII) and X (FX). Here we show that soluble EPCR regulates the interaction of FX with human or mouse tissue factor (TF)-FVIIa complexes. Mutagenesis of the FVIIa 4-carboxyglutamic acid domain and dose titrations with FX showed that EPCR interacted primarily with FX to attenuate FX activation in lipid-free assay systems. In human cell models of TF signaling, antibody inhibition of EPCR selectively blocked PAR activation by the ternary TF-FVIIa-FXa complex but not by the non-coagulant TF-FVIIa binary complex. Heterologous expression of EPCR promoted PAR1 and PAR2 cleavage by FXa in the ternary complex but did not alter PAR2 cleavage by TF-FVIIa. In murine smooth muscle cells that constitutively express EPCR and TF, thrombin and FVIIa/FX but not FVIIa alone induced PAR1-dependent signaling. Although thrombin signaling was unchanged, cells with genetically reduced levels of EPCR no longer showed a signaling response to the ternary complex. These results demonstrate that EPCR interacts with the ternary TF coagulation initiation complex to enable PAR signaling and suggest that EPCR may play a role in regulating the biology of TF-expressing extravascular and vessel wall cells that are exposed to limited concentrations of FVIIa and FX provided by ectopic synthesis or vascular leakage."xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.201228"xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/author | "Teyton L."xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/author | "Petersen L.C."xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/author | "Esmon C.T."xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/author | "Persson E."xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/author | "Ruf W."xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/author | "Petersen H.H."xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/author | "Esmon N."xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/author | "Disse J."xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/author | "Larsen K.S."xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/pages | "5756-5767"xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/title | "The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors."xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21149441 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21149441 |
| http://purl.uniprot.org/citations/21149441 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21149441 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGS5-mappedCitation-21149441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21149441 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J088-mappedCitation-21149441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21149441 |
| http://purl.uniprot.org/uniprot/#_A2AUV5-mappedCitation-21149441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21149441 |
| http://purl.uniprot.org/uniprot/#_B2R6M5-mappedCitation-21149441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21149441 |
| http://purl.uniprot.org/uniprot/#_B4DLS3-mappedCitation-21149441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21149441 |
| http://purl.uniprot.org/uniprot/#_Q71UT7-mappedCitation-21149441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21149441 |