| http://purl.uniprot.org/citations/21151042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21151042 | http://www.w3.org/2000/01/rdf-schema#comment | "The proapoptotic Bcl2 homology domain 3(BH3)-only protein Bim is controlled by stringent post-translational regulation, predominantly through alterations in phosphorylation status. To identify new kinases involved in its regulation, we carried out a yeast two-hybrid screen using a non-spliceable variant of the predominant isoform--Bim(EL)--as the bait and identified the regulatory subunit of cyclic-AMP-dependent protein kinase A--PRKAR1A--as an interacting partner. We also show that protein kinase A (PKA) is a Bim(EL) isoform-specific kinase that promotes its stabilization. Inhibition of PKA or mutation of the PKA phosphorylation site within Bim(EL) resulted in its accelerated proteasome-dependent degradation. These results might have implications for human diseases that are characterized by abnormally increased PKA activity, such as the Carney complex and dilated cardiomyopathy."xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2010.190"xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/author | "Huang D.C."xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/author | "Weston R."xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/author | "Strasser A."xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/author | "Puthalakath H."xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/author | "Anderton H."xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/author | "Goel P."xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/author | "Moujalled D."xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/author | "Coley A."xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/author | "Ninnis R."xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/pages | "77-83"xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/title | "Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim."xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/21151042 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21151042 |
| http://purl.uniprot.org/citations/21151042 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21151042 |
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| http://purl.uniprot.org/uniprot/#_A2AI69-mappedCitation-21151042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21151042 |
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| http://purl.uniprot.org/uniprot/#_Q3ULA2-mappedCitation-21151042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21151042 |
| http://purl.uniprot.org/uniprot/#_O43521-mappedCitation-21151042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21151042 |