| http://purl.uniprot.org/citations/21151134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21151134 | http://www.w3.org/2000/01/rdf-schema#comment | "A neuron forms thousands of presynaptic nerve terminals on its axons, far removed from the cell body. The protein CSPα resides in presynaptic terminals, where it forms a chaperone complex with Hsc70 and SGT. Deletion of CSPα results in massive neurodegeneration that impairs survival in mice and flies. In CSPα-knockout mice, levels of presynaptic SNARE complexes and the SNARE protein SNAP-25 are reduced, suggesting that CSPα may chaperone SNARE proteins, which catalyse synaptic vesicle fusion. Here, we show that the CSPα-Hsc70-SGT complex binds directly to monomeric SNAP-25 to prevent its aggregation, enabling SNARE-complex formation. Deletion of CSPα produces an abnormal SNAP-25 conformer that inhibits SNARE-complex formation, and is subject to ubiquitylation and proteasomal degradation. Even in wild-type mouse terminals, SNAP-25 degradation is regulated by synaptic activity; this degradation is decreased by CSPα overexpression, and enhanced by CSPα deletion. Thus, SNAP-25 function is maintained during rapid SNARE cycles by equilibrium between CSPα-dependent chaperoning and ubiquitin-dependent degradation, revealing unique protein quality-control machinery within the presynaptic compartment."xsd:string |
| http://purl.uniprot.org/citations/21151134 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2131"xsd:string |
| http://purl.uniprot.org/citations/21151134 | http://purl.uniprot.org/core/author | "Sharma M."xsd:string |
| http://purl.uniprot.org/citations/21151134 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/21151134 | http://purl.uniprot.org/core/author | "Burre J."xsd:string |
| http://purl.uniprot.org/citations/21151134 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21151134 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/21151134 | http://purl.uniprot.org/core/pages | "30-39"xsd:string |
| http://purl.uniprot.org/citations/21151134 | http://purl.uniprot.org/core/title | "CSPalpha promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity."xsd:string |
| http://purl.uniprot.org/citations/21151134 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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