| http://purl.uniprot.org/citations/21157432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21157432 | http://www.w3.org/2000/01/rdf-schema#comment | "The Carma1-Bcl10-Malt1 (CBM) complex bridges T-cell receptor (TCR) signalling to the canonical IκB kinase (IKK)/NF-κB pathway. NF-κB activation is triggered by PKCθ-dependent phosphorylation of Carma1 after TCR/CD28 co-stimulation. PKCθ-phosphorylated Carma1 was suggested to function as a molecular scaffold that recruits preassembled Bcl10-Malt1 complexes to the membrane. We have identified the serine-threonine protein phosphatase PP2A regulatory subunit Aα (PPP2R1A) as a novel interaction partner of Carma1. PPP2R1A is associated with Carma1 in resting as well as activated T cells in the context of the active CBM complex. By siRNA-mediated knockdown and in vitro dephosphorylation, we demonstrate that PP2A removes PKCθ-dependent phosphorylation of Ser645 in Carma1, and show that maintenance of this phosphorylation is correlated with increased T-cell activation. As a result of PP2A inactivation, we find that enhanced Carma1 S645 phosphorylation augments CBM complex formation, NF-κB activation and IL-2 or IFN-γ production after stimulation of Jurkat T cells or murine Th1 cells. Thus, our data define PP2A-mediated dephosphorylation of Carma1 as a critical step to limit T-cell activation and effector cytokine production."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.331"xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/author | "Kurosaki T."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/author | "Shinohara H."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/author | "Demski K."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/author | "Hadian K."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/author | "Heissmeyer V."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/author | "Krappmann D."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/author | "Schimmack G."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/author | "Duwel M."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/author | "Beisker W."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/author | "Eitelhuber A.C."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/author | "Warth S."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/pages | "594-605"xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/title | "Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation."xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/21157432 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21157432 |
| http://purl.uniprot.org/citations/21157432 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21157432 |
| http://purl.uniprot.org/uniprot/#_A0A192GQE0-mappedCitation-21157432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21157432 |
| http://purl.uniprot.org/uniprot/#_A0A192GQF6-mappedCitation-21157432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21157432 |
| http://purl.uniprot.org/uniprot/#_A0A192GQG0-mappedCitation-21157432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21157432 |
| http://purl.uniprot.org/uniprot/#_A0A192GQM1-mappedCitation-21157432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21157432 |