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| http://purl.uniprot.org/citations/21158569 | http://www.w3.org/2000/01/rdf-schema#comment | "Thioredoxin (TRX) is a ubiquitous redox protein that is involved in numerous biological functions, including the first unique step in DNA synthesis. TRX provides control over a number of transcription factors affecting cell proliferation and death through a mechanism referred to as redox regulation. In mammals, there are at least 3 members of the TRX family: TRX1, TRX2, and sperm TRX. To investigate the role of TRX1 and TRX2 in human adipose tissue-derived mesenchymal stem cells (hADSC), we modulated TRX1 and TRX2 expressions in hADSC using a lentiviral gene transfer system and small interfering RNA technique. Reverse transcription-polymerase chain reaction analysis confirmed the changes in expression of TRX1 and TRX2 in lentivirus-transduced or small interfering RNA-transfected cells. Although overexpression of TRX1 and TRX2 did not affect the differentiation of hADSC into adipogenic and osteogenic lineages, it increased the proliferation of hADSC compared with control lentivirus-transduced cells, decreased reactive oxygen species production, and inhibited oxidant-induced cell death. Downregulation of TRX1 and TRX2 inhibited cell proliferation. The treatment of U0126 blocked TRX-induced increase in cell proliferation. Overexpression of TRX1 and TRX2 increased ERK1/2 phosphorylation, nuclear factor-kappaB activation, and β-catenin/Tcf promoter activities and inhibited lucine zipper tumor suppressor 2 expression. On the contrary, downregulation of TRX1 and TRX2 expression induced inhibition of ERK1/2 phosphorylation, nuclear factor-kappaB activation, and β-catenin/Tcf promoter activities and increased lucine zipper tumor suppressor 2 expression. Activation of Wnt signal increased ERK1/2 activities in hADSC. These results indicated that TRX1 and TRX2 regulate the proliferation and survival of hADSC; these processes are mediated by the activation of ERK1/2."xsd:string |
| http://purl.uniprot.org/citations/21158569 | http://purl.org/dc/terms/identifier | "doi:10.1089/scd.2010.0364"xsd:string |
| http://purl.uniprot.org/citations/21158569 | http://purl.uniprot.org/core/author | "Lee B.J."xsd:string |
| http://purl.uniprot.org/citations/21158569 | http://purl.uniprot.org/core/author | "Song J.S."xsd:string |
| http://purl.uniprot.org/citations/21158569 | http://purl.uniprot.org/core/author | "Bae Y.C."xsd:string |
| http://purl.uniprot.org/citations/21158569 | http://purl.uniprot.org/core/author | "Jung J.S."xsd:string |
| http://purl.uniprot.org/citations/21158569 | http://purl.uniprot.org/core/author | "Cho H.H."xsd:string |
| http://purl.uniprot.org/citations/21158569 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21158569 | http://purl.uniprot.org/core/name | "Stem Cells Dev"xsd:string |
| http://purl.uniprot.org/citations/21158569 | http://purl.uniprot.org/core/pages | "1529-1537"xsd:string |
| http://purl.uniprot.org/citations/21158569 | http://purl.uniprot.org/core/title | "Role of thioredoxin 1 and thioredoxin 2 on proliferation of human adipose tissue-derived mesenchymal stem cells."xsd:string |
| http://purl.uniprot.org/citations/21158569 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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