| http://purl.uniprot.org/citations/21161732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21161732 | http://www.w3.org/2000/01/rdf-schema#comment | "Over-expression of RhoA in esophageal squamous cell carcinoma (ESCC) indicates a poor prognosis and is correlated with the tumor-node-metastasis (TNM) clinical classification. However, until now RhoA function in the ESCC progression remains to be established. We employed adenovirus-mediated small hairpin RNA (shRNA) against human RhoA (Ad-sh-RhoA) to efficiently silence target gene expression in RhoA-expressing Eca-109 ESCC cells at both protein and mRNA levels. Consequently, Ad-sh-RhoA reduced the proliferation and migration of Eca-109 cells assayed by MTT assay and cell wound healing, respectively. Moreover, Ad-sh-RhoA increased cell apoptosis and inhibited the cell cycle G1-S-phase progression of Eca-109 cells assessed by flow cytometry. Finally, in a nude mouse model, intratumoral injections of adenovirus-delivered RhoA shRNA every 3 days for 20 days significantly inhibited the growth and angiogenesis of xenografted Eca-109 tumors. In summary, these data indicate that RhoA may be a key molecule in ESCC cells, and thus, specific inhibition of the Rho signaling pathway with adenovirus-delivered shRNA represents a promising approach for the treatment of aggressive ESCC."xsd:string |
| http://purl.uniprot.org/citations/21161732 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12032-010-9774-y"xsd:string |
| http://purl.uniprot.org/citations/21161732 | http://purl.uniprot.org/core/author | "Cheng Y."xsd:string |
| http://purl.uniprot.org/citations/21161732 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/21161732 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/21161732 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/21161732 | http://purl.uniprot.org/core/author | "Xue Y."xsd:string |
| http://purl.uniprot.org/citations/21161732 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/21161732 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/21161732 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21161732 | http://purl.uniprot.org/core/name | "Med Oncol"xsd:string |
| http://purl.uniprot.org/citations/21161732 | http://purl.uniprot.org/core/pages | "119-126"xsd:string |
| http://purl.uniprot.org/citations/21161732 | http://purl.uniprot.org/core/title | "Adenovirus-mediated RhoA shRNA suppresses growth of esophageal squamous cell carcinoma cells in vitro and in vivo."xsd:string |
| http://purl.uniprot.org/citations/21161732 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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