| http://purl.uniprot.org/citations/21162913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21162913 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo investigate the cutaneous adverse reactions to antiepileptic drugs (AEDs), clinical characteristic and the association with HLA-B*1502.MethodsA retrospective analysis of four cases of antiepileptic drug hypersensitive syndrome (AHS) were performed on the basis of clinical data, cutaneous adverse reactions to carbamazepine (CBZ) (n = 2) including Stevens-Johnson syndrome (SJS) (n = 1) and hypersensitivity syndrome (HSS) (n = 1); phenobarbital-induced HSS (n = 1) and oxcarbazepine (OXC)-induced HSS (n = 1). All patients received the examinations of polymerase chain reaction (PCR) with sequence specific primers to analyze HLA-B*1502. Two healthy subjects had no history of using antiepileptic drugs as the control.ResultsAll patients had manifestations of fever, eruption, mucosal involvement and visceral injury. Two cases were diagnosed as Stevens-Johnson syndrome associated with apparent bullae formation. Genotype positive for HLA-B*1502 was association with 2 patients with CBZ/OXC-induced SJS while the other 1 case of CBZ and 1 case of phenobarbital-induced HSS were genotype non-HLA-B*1502.ConclusionAHS usually occurs within 1 to 2 weeks after initiation of AEDs therapy. The typical presentations are fever, eruption and internal organ involvements, etc. The epileptic patients with CBZ/OXC-induced SJS are related with HLA-B*1502 genotype. But it is not found in HSS patients."xsd:string |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/author | "Hu J.S."xsd:string |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/author | "Sun D."xsd:string |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/author | "He C.Y."xsd:string |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/author | "Shi Y.W."xsd:string |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/author | "Liu Z.S."xsd:string |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/author | "Liao W.P."xsd:string |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/author | "Wang F.L."xsd:string |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/author | "Wu G.F."xsd:string |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/name | "Zhonghua Yi Xue Za Zhi"xsd:string |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/pages | "2763-2766"xsd:string |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/title | "[Hypersensitivity syndrome reactions to antiepileptic drugs, clinical characteristic and association with HLA-B*1502]."xsd:string |
| http://purl.uniprot.org/citations/21162913 | http://purl.uniprot.org/core/volume | "90"xsd:string |
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