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| http://purl.uniprot.org/citations/2116362 | http://www.w3.org/2000/01/rdf-schema#comment | "A novel B-cell-specific transcription factor, BSAP, was identified as a mammalian homolog of the sea urchin protein TSAP, which interacts with the promoters of four tissue-specific late histone H2A-2 and H2B-2 genes. As shown by mobility-shift, methylation interference, and mutational analyses, the mammalian protein BSAP recognizes all four sea urchin binding sites in a manner indistinguishable from TSAP; however, the two proteins differ in molecular weight. BSAP is exclusively restricted to the B-cell lineage of lymphoid differentiation. Its expression appears to be activated during pro-B-cell development, is abundant at the pre-B- and mature B-cell stages, but is absent in terminally differentiated plasma cells. Moreover, BSAP is clearly a B-cell-specific transcription factor, as a wild-type but not a mutant TSAP-binding site of the sea urchin functions only in transfected B cells as an upstream promoter element. Competition experiments did not reveal any high-affinity binding site for BSAP in known regulatory regions of immunoglobulin and class II major histocompatibility (MHC) genes, suggesting that BSAP is a regulator of a different set of B-lymphoid-specific genes."xsd:string |
| http://purl.uniprot.org/citations/2116362 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.4.5.849"xsd:string |
| http://purl.uniprot.org/citations/2116362 | http://purl.uniprot.org/core/author | "Barberis A."xsd:string |
| http://purl.uniprot.org/citations/2116362 | http://purl.uniprot.org/core/author | "Busslinger M."xsd:string |
| http://purl.uniprot.org/citations/2116362 | http://purl.uniprot.org/core/author | "Vitelli L."xsd:string |
| http://purl.uniprot.org/citations/2116362 | http://purl.uniprot.org/core/author | "Widenhorn K."xsd:string |
| http://purl.uniprot.org/citations/2116362 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2116362 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/2116362 | http://purl.uniprot.org/core/pages | "849-859"xsd:string |
| http://purl.uniprot.org/citations/2116362 | http://purl.uniprot.org/core/title | "A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation."xsd:string |
| http://purl.uniprot.org/citations/2116362 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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