| http://purl.uniprot.org/citations/21164521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21164521 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal apoptosis has a major role during development and aberrant apoptosis contributes to the pathology of certain neurological conditions. Studies with nerve growth factor (NGF)-dependent sympathetic neurons have provided important insights into the molecular mechanisms of neuronal apoptosis and the signalling pathways that regulate the cell death programme in neurons. The BH3-only protein Bim is a critical mediator of apoptosis in many cell types and in sympathetic neurons is required for NGF withdrawal-induced death. However, regulation of bim expression is complex and remains incompletely understood. We report that a conserved inverted CCAAT box (ICB) in the rat bim promoter is bound by the heterotrimeric transcription factor NF-Y. Interestingly, NF-Y is required for bim promoter activity and its induction following NGF withdrawal. We demonstrate that NF-Y activity is essential for endogenous Bim expression and contributes to NGF withdrawal-induced death. Furthermore, we find that the transcriptional coactivators CBP and p300 interact with NF-Y and FOXO3a and bind to this region of the bim promoter. The amount of CBP/p300 bound to bim increases after NGF deprivation and inhibition of CBP/p300 activity reduces bim induction. Our results indicate that NF-Y cooperates with FOXO3a to recruit CBP/p300 to the bim promoter to form a stable multi-protein/DNA complex that activates bim transcription after survival factor withdrawal."xsd:string |
| http://purl.uniprot.org/citations/21164521 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2010.166"xsd:string |
| http://purl.uniprot.org/citations/21164521 | http://purl.uniprot.org/core/author | "Hughes R."xsd:string |
| http://purl.uniprot.org/citations/21164521 | http://purl.uniprot.org/core/author | "Ham J."xsd:string |
| http://purl.uniprot.org/citations/21164521 | http://purl.uniprot.org/core/author | "Lassot I."xsd:string |
| http://purl.uniprot.org/citations/21164521 | http://purl.uniprot.org/core/author | "Kristiansen M."xsd:string |
| http://purl.uniprot.org/citations/21164521 | http://purl.uniprot.org/core/author | "Desagher S."xsd:string |
| http://purl.uniprot.org/citations/21164521 | http://purl.uniprot.org/core/author | "Mantovani R."xsd:string |
| http://purl.uniprot.org/citations/21164521 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21164521 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/21164521 | http://purl.uniprot.org/core/pages | "937-947"xsd:string |
| http://purl.uniprot.org/citations/21164521 | http://purl.uniprot.org/core/title | "NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons."xsd:string |
| http://purl.uniprot.org/citations/21164521 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/21164521 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21164521 |
| http://purl.uniprot.org/citations/21164521 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21164521 |
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