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http://purl.uniprot.org/citations/21166186http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21166186http://www.w3.org/2000/01/rdf-schema#comment"

Aim

To explore the role of novel protein kinases C (nPKCs) in the development of cerebral hypoxic preconditioning.

Methods

By using the mice model of hypoxic preconditioning, which was established before in our lab, the biochemistry techniques of SDS-PAGE and Western blot were applied to observe the effects of repetitive hypoxic exposure (H0-H4) on nPKCs (nPKCepsilon, delta, eta, mu and theta) membrane translocation in hippocampus and cortex.

Results

nPKCepsilon membrane translocation was increased in response to the hypoxic exposure times in the hippocampus (H0: 41.6% +/-1.4% vs. H1-H4: 46.9% +/- 4.5%, 52.7% +/- 3.9%, 58.8% +/- 2.7% and 61.3% +/-3.7%) and cortex (H0: 38.4% +/- 4.5% vs. 42.4% +/- 5.0%, 48.7% +/-6.5%, 55.3% +/- 8.9% and 61.2% +/-10.2%) of mice, and there were statistic significances among H2, H3 and H4 in hippocampus, and H3 and H4 in cortex respectively (P < 0.01). But for nPKCdelta, eta, mu and theta membrane translocation, there were no any significant changes in hippocampus and cortex of hypoxic preconditioned mice.

Conclusion

nPKCepsilon may play an important role in the development of cerebral hypoxic preconditioning, but it need more evidence to prove."xsd:string
http://purl.uniprot.org/citations/21166186http://purl.uniprot.org/core/author"Han S."xsd:string
http://purl.uniprot.org/citations/21166186http://purl.uniprot.org/core/author"Wang X.M."xsd:string
http://purl.uniprot.org/citations/21166186http://purl.uniprot.org/core/author"Li J.F."xsd:string
http://purl.uniprot.org/citations/21166186http://purl.uniprot.org/core/author"Lu G.W."xsd:string
http://purl.uniprot.org/citations/21166186http://purl.uniprot.org/core/author"Zu P.Y."xsd:string
http://purl.uniprot.org/citations/21166186http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/21166186http://purl.uniprot.org/core/name"Zhongguo Ying Yong Sheng Li Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/21166186http://purl.uniprot.org/core/pages"105-109"xsd:string
http://purl.uniprot.org/citations/21166186http://purl.uniprot.org/core/title"[Hypoxic preconditioning increase nPKCepsilon membrane translocation in the brain of mice]."xsd:string
http://purl.uniprot.org/citations/21166186http://purl.uniprot.org/core/volume"20"xsd:string
http://purl.uniprot.org/citations/21166186http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21166186
http://purl.uniprot.org/citations/21166186http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21166186
http://purl.uniprot.org/uniprot/#_P16054-mappedCitation-21166186http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21166186
http://purl.uniprot.org/uniprot/#_Q8C944-mappedCitation-21166186http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21166186
http://purl.uniprot.org/uniprot/P16054http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21166186
http://purl.uniprot.org/uniprot/Q8C944http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21166186