| http://purl.uniprot.org/citations/21166899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21166899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21166899 | http://www.w3.org/2000/01/rdf-schema#comment | "In this work we describe the identification of a copper-inducible regulon in Mycobacterium tuberculosis (Mtb). Among the regulated genes was Rv0190/MT0200, a paralogue of the copper metalloregulatory repressor CsoR. The five-locus regulon, which includes a gene that encodes the copper-protective metallothionein MymT, was highly induced in wild-type Mtb treated with copper, and highly expressed in an Rv0190/MT0200 mutant. Importantly, the Rv0190/MT0200 mutant was hyper-resistant to copper. The promoters of all five loci share a palindromic motif that was recognized by the gene product of Rv0190/MT0200. For this reason we named Rv0190/MT0200 RicR for regulated in copper repressor. Intriguingly, several of the RicR-regulated genes, including MymT, are unique to pathogenic Mycobacteria. The identification of a copper-responsive regulon specific to virulent mycobacterial species suggests copper homeostasis must be maintained during an infection. Alternatively, copper may provide a cue for the expression of genes unrelated to metal homeostasis, but nonetheless necessary for survival in a host."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2958.2010.07431.x"xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2958.2010.07431.x"xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Darwin K.H."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Darwin K.H."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Festa R.A."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Festa R.A."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Peterson S.N."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Peterson S.N."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Bishai W.R."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Bishai W.R."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Jones M.B."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Jones M.B."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Butler-Wu S."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Butler-Wu S."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Gerads R."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Gerads R."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Sinsimer D."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/author | "Sinsimer D."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/name | "Mol. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/21166899 | http://purl.uniprot.org/core/name | "Mol. Microbiol."xsd:string |