| http://purl.uniprot.org/citations/21167753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21167753 | http://www.w3.org/2000/01/rdf-schema#comment | "B cell development requires the coordinated action of transcription factors and cytokines, in particular interleukin-7 (IL-7). We report that mice lacking the POZ (Poxvirus and zinc finger) domain of the transcription factor Miz-1 (Zbtb17(ΔPOZ/ΔPOZ)) almost entirely lacked follicular B cells, as shown by the fact that their progenitors failed to activate the Jak-Stat5 pathway and to upregulate the antiapoptotic gene Bcl2 upon IL-7 stimulation. We show that Miz-1 exerted a dual role in the interleukin-7 receptor (IL-7R) pathway by directly repressing the Janus kinase (Jak) inhibitor suppressor of cytokine signaling 1 (Socs1) and by activating Bcl2 expression. Zbtb17(ΔPOZ/ΔPOZ) (Miz-1-deficient) B cell progenitors had low expression of early B cell genes as transcription factor 3 (Tcf3) and early B cell factor 1 (Ebf1) and showed a propensity for apoptosis. Only the combined re-expression of Bcl2 and Ebf1 could reconstitute the ability of Miz-1-deficient precursors to develop into CD19(+) B cells."xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2010.11.028"xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://purl.uniprot.org/core/author | "Herold S."xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://purl.uniprot.org/core/author | "Eilers M."xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://purl.uniprot.org/core/author | "Kosan C."xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://purl.uniprot.org/core/author | "Moroy T."xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://purl.uniprot.org/core/author | "Saba I."xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://purl.uniprot.org/core/author | "Godmann M."xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://purl.uniprot.org/core/author | "Herkert B."xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21167753 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://purl.uniprot.org/core/pages | "917-928"xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://purl.uniprot.org/core/title | "Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/21167753 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21167753 |
| http://purl.uniprot.org/citations/21167753 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21167753 |
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| http://purl.uniprot.org/uniprot/#_A0A494B929-mappedCitation-21167753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21167753 |
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| http://purl.uniprot.org/uniprot/#_A0A3Q4EGT0-mappedCitation-21167753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21167753 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EHG2-mappedCitation-21167753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21167753 |
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| http://purl.uniprot.org/uniprot/#_A0A3Q4EII3-mappedCitation-21167753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21167753 |
| http://purl.uniprot.org/uniprot/#_A6H6B9-mappedCitation-21167753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21167753 |