| http://purl.uniprot.org/citations/21169383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21169383 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription enhancer factor 3 (TEF3) is known to regulate the expression of muscle-specific genes and to play important roles in muscle development and diseases. However, little is known about its role in vascular endothelial growth factor (VEGF)-induced angiogenesis. Most recently, we discovered a novel function of TEF3, in which TEF3 is required for the up-regulation of a proangiogenic factor, Down syndrome candidate region 1 isoform 1L (DSCR1-1L), induced by VEGF-A(165) in endothelial cells. Overexpression of TEF3 isoform 1 (TEF3-1) is sufficient to induce DSCR1-1L expression. Here, we report that knocking down the expression of TEF3 almost completely inhibits VEGF-A(165)-induced proliferation, migration, tube formation, formation of F-actin stress fiber, and in vivo Matrigel angiogenesis. This inhibition cannot be rescued by DSCR1-1L overexpression. Further, overexpression of TEF3-1, but not its nuclear localization signal-deletion mutant (TEF3-ΔNLS), induces human umbilical vein endothelial cell proliferation, migration, tube formation, and formation of F-actin stress fiber, even in the absence of VEGF-A(165) stimulation, which is partially inhibited by DSCR1-1L silencing. Our data demonstrate that TEF3, mainly its nuclear localization, is required for VEGF-A(165)-induced endothelial proliferation, migration, tube formation, and in vivo Matrigel angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/21169383 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.10-167619"xsd:string |
| http://purl.uniprot.org/citations/21169383 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/21169383 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/21169383 | http://purl.uniprot.org/core/author | "Zhao D."xsd:string |
| http://purl.uniprot.org/citations/21169383 | http://purl.uniprot.org/core/author | "Zeng H."xsd:string |
| http://purl.uniprot.org/citations/21169383 | http://purl.uniprot.org/core/author | "James L."xsd:string |
| http://purl.uniprot.org/citations/21169383 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21169383 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/21169383 | http://purl.uniprot.org/core/pages | "1188-1197"xsd:string |
| http://purl.uniprot.org/citations/21169383 | http://purl.uniprot.org/core/title | "Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor."xsd:string |
| http://purl.uniprot.org/citations/21169383 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/21169383 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21169383 |
| http://purl.uniprot.org/citations/21169383 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21169383 |
| http://purl.uniprot.org/uniprot/#_Q15561-mappedCitation-21169383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21169383 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4E5-mappedCitation-21169383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21169383 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4F2-mappedCitation-21169383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21169383 |
| http://purl.uniprot.org/uniprot/#_D3DUQ6-mappedCitation-21169383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21169383 |
| http://purl.uniprot.org/uniprot/#_Q53GI4-mappedCitation-21169383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21169383 |
| http://purl.uniprot.org/uniprot/Q15561 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21169383 |
| http://purl.uniprot.org/uniprot/A0A0S2Z4F2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21169383 |
| http://purl.uniprot.org/uniprot/Q53GI4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21169383 |
| http://purl.uniprot.org/uniprot/D3DUQ6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21169383 |
| http://purl.uniprot.org/uniprot/A0A0S2Z4E5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21169383 |