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http://purl.uniprot.org/citations/21169521http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21169521http://www.w3.org/2000/01/rdf-schema#comment"BAFF is expressed primarily by macrophages and DCs. BAFF stimulates the differentiation and survival of B cells and induces Ig production. We have demonstrated previously that murine macrophages treated with TGF-β1 or IFN-γ express membrane-bound and soluble forms of BAFF. The ability of these two forms of BAFF to induce expression of AID, which plays a critical role in Ig CSR in B cells, was investigated. Both forms of BAFF, derived from macrophages activated by IFN-γ or TGF-β1, can increase AID expression. Subsequent analysis of BAFF signaling suggested that BAFF induces AID through BCMA, a BAFF-receptor, and p38MAPK and CREB act as intermediates in AID expression. In addition, JNK and AP-1 have similar activities. Our findings suggest that macrophage-derived BAFF stimulates B cells to express AID through BCMA and at least two different pathways, including the p38MAPK/CREB and the JNK/AP-1 pathways."xsd:string
http://purl.uniprot.org/citations/21169521http://purl.org/dc/terms/identifier"doi:10.1189/jlb.1209787"xsd:string
http://purl.uniprot.org/citations/21169521http://purl.uniprot.org/core/author"Kim H.A."xsd:string
http://purl.uniprot.org/citations/21169521http://purl.uniprot.org/core/author"Kim P.H."xsd:string
http://purl.uniprot.org/citations/21169521http://purl.uniprot.org/core/author"Seo G.Y."xsd:string
http://purl.uniprot.org/citations/21169521http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21169521http://purl.uniprot.org/core/name"J Leukoc Biol"xsd:string
http://purl.uniprot.org/citations/21169521http://purl.uniprot.org/core/pages"393-398"xsd:string
http://purl.uniprot.org/citations/21169521http://purl.uniprot.org/core/title"Macrophage-derived BAFF induces AID expression through the p38MAPK/CREB and JNK/AP-1 pathways."xsd:string
http://purl.uniprot.org/citations/21169521http://purl.uniprot.org/core/volume"89"xsd:string
http://purl.uniprot.org/citations/21169521http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21169521
http://purl.uniprot.org/citations/21169521http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21169521
http://purl.uniprot.org/uniprot/#_A0A0U5J6R6-mappedCitation-21169521http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21169521
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http://purl.uniprot.org/uniprot/#_Q61440-mappedCitation-21169521http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21169521
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http://purl.uniprot.org/uniprot/#_Q61442-mappedCitation-21169521http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21169521
http://purl.uniprot.org/uniprot/#_Q61443-mappedCitation-21169521http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21169521
http://purl.uniprot.org/uniprot/#_Q52L79-mappedCitation-21169521http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21169521
http://purl.uniprot.org/uniprot/#_Q3V255-mappedCitation-21169521http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21169521