| http://purl.uniprot.org/citations/21169726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21169726 | http://www.w3.org/2000/01/rdf-schema#comment | "Aldosterone synthase (CYP11B2) is responsible for the final step in aldosterone synthesis and is importantly regulated by angiotensin-II (Ang II) through diverse pathways. However, under pathological conditions, such as in hyperaldosteronism, the regulation becomes disordered. The transcription factor steroidogenic factor-1 (SF-1) is important in regulating the endocrine system and is overexpressed in aldosterone-producing adenoma (APA), a common cause of hyperaldosteronism. Overexpression of SF-1 has been extensively studied, but little in-depth information is available regarding the effects of inhibitory SF-1 on CYP11B2 and Ang II. In this paper, we have investigated the roles of down-regulated SF-1 in basal and Ang II-induced CYP11B2 expression using SF-1-specific short hairpin RNA. Inhibitory SF-1 was found to decrease the sensitivity of CYP11B2 and aldosterone to Ang II stimulation, whereas a down-regulation of SF-1 enhanced basal CYP11B2 expression and aldosterone production in H295R cells. Considering these differential effects of SF-1 on aldosterone production, these results might provide a new insight into the understanding of hyperaldosteronism."xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.org/dc/terms/identifier | "doi:10.3275/7413"xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/author | "Ouyang J."xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/author | "Hu D."xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/author | "Shi T."xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/name | "J Endocrinol Invest"xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/pages | "671-675"xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/title | "Differential effects of down-regulated steroidogenic factor-1 on basal and angiotensin II-induced aldosterone secretion."xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/21169726 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21169726 |
| http://purl.uniprot.org/citations/21169726 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21169726 |
| http://purl.uniprot.org/uniprot/#_P97782-mappedCitation-21169726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21169726 |
| http://purl.uniprot.org/uniprot/#_P33242-mappedCitation-21169726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21169726 |
| http://purl.uniprot.org/uniprot/#_Q3U0G1-mappedCitation-21169726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21169726 |
| http://purl.uniprot.org/uniprot/Q3U0G1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21169726 |
| http://purl.uniprot.org/uniprot/P33242 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21169726 |
| http://purl.uniprot.org/uniprot/P97782 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21169726 |