| http://purl.uniprot.org/citations/21170036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21170036 | http://www.w3.org/2000/01/rdf-schema#comment | "Bicoid (Bcd) is a morphogenetic protein that instructs patterning along the anterior-posterior (A-P) axis in Drosophila melanogaster embryos. Despite extensive studies, what controls the formation of a normal concentration gradient of Bcd remains an unresolved and controversial question. Here, we show that Bcd protein degradation is mediated by the ubiquitin-proteasome pathway. We have identified an F-box protein, encoded by fates-shifted (fsd), that has an important role in Bcd protein degradation by targeting it for ubiquitylation. Embryos from females lacking fsd have an altered Bcd gradient profile, resulting in a shift of the fatemap along the A-P axis. Our study is an experimental demonstration that, contrary to an alternative hypothesis, Bcd protein degradation is required for normal gradient formation and developmental fate determination."xsd:string |
| http://purl.uniprot.org/citations/21170036 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2141"xsd:string |
| http://purl.uniprot.org/citations/21170036 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/21170036 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/21170036 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21170036 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/21170036 | http://purl.uniprot.org/core/pages | "22-29"xsd:string |
| http://purl.uniprot.org/citations/21170036 | http://purl.uniprot.org/core/title | "Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos."xsd:string |
| http://purl.uniprot.org/citations/21170036 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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| http://purl.uniprot.org/uniprot/A1Z9A5#attribution-15B634333DA5CA702044E4D202688A45 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21170036 |
| http://purl.uniprot.org/uniprot/A1Z9A5#attribution-587ACC6D9ADACC4B1D62358808CAC22C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21170036 |
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| http://purl.uniprot.org/uniprot/Q8T401#attribution-15B634333DA5CA702044E4D202688A45 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21170036 |
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| http://purl.uniprot.org/uniprot/#_P10734-mappedCitation-21170036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21170036 |