| http://purl.uniprot.org/citations/21172655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21172655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21172655 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic deletion of the mitochondrial deacetylase sirtuin-3 (Sirt3) results in increased mitochondrial superoxide, a tumor-permissive environment, and mammary tumor development. MnSOD contains a nutrient- and ionizing radiation (IR)-dependent reversible acetyl-lysine that is hyperacetylated in Sirt3⁻/⁻ livers at 3 months of age. Livers of Sirt3⁻/⁻ mice exhibit decreased MnSOD activity, but not immunoreactive protein, relative to wild-type livers. Reintroduction of wild-type but not deacetylation null Sirt3 into Sirt3⁻/⁻ MEFs deacetylated lysine and restored MnSOD activity. Site-directed mutagenesis of MnSOD lysine 122 to an arginine, mimicking deacetylation (lenti-MnSOD(K122-R)), increased MnSOD activity when expressed in MnSOD⁻/⁻ MEFs, suggesting acetylation directly regulates function. Furthermore, infection of Sirt3⁻/⁻ MEFs with lenti-MnSOD(K122-R) inhibited in vitro immortalization by an oncogene (Ras), inhibited IR-induced genomic instability, and decreased mitochondrial superoxide. Finally, IR was unable to induce MnSOD deacetylation or activity in Sirt3⁻/⁻ livers, and these irradiated livers displayed significant IR-induced cell damage and microvacuolization in their hepatocytes."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2010.12.013"xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2010.12.013"xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Jiang H."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Jiang H."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Hill S."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Hill S."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Tao R."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Tao R."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Gius D."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Gius D."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Spitz D.R."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Spitz D.R."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Flynn C.R."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Flynn C.R."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Olivier A.K."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Olivier A.K."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Coleman M.C."xsd:string |
| http://purl.uniprot.org/citations/21172655 | http://purl.uniprot.org/core/author | "Coleman M.C."xsd:string |