| http://purl.uniprot.org/citations/21179444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21179444 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundGranulocytes and monocytes/macrophages differentiate from common myeloid progenitor cells. Granulocyte colony-stimulating factor (G-CSF) and CD137 (4-1BB, TNFRSF9) are growth and differentiation factors that induce granulocyte and macrophage survival and differentiation, respectively. This study describes the influence of G-CSF and recombinant CD137-Fc protein on myelopoiesis.Methodology/principal findingsBoth, G-CSF and CD137 protein support proliferation and survival of murine bone marrow cells. G-CSF enhances granulocyte numbers while CD137 protein enhances macrophage numbers. Both growth factors together give rise to more cells than each factor alone. Titration of G-CSF and CD137 protein dose-dependently changes the granulocyte/macrophage ratio in bone marrow cells. Both factors individually induce proliferation of hematopoietic progenitor cells (lin-, c-kit+) and differentiation to granulocytes and macrophages, respectively. The combination of G-CSF and CD137 protein further increases proliferation, and results in a higher number of macrophages than CD137 protein alone, and a lower number of granulocytes than G-CSF alone demonstrating that CD137 protein-induced monocytic differentiation is dominant over G-CSF-induced granulocytic differentiation. CD137 protein induces monocytic differentiation even in early hematopoietic progenitor cells, the common myeloid progenitors and the granulocyte macrophage progenitors.Conclusions/significanceThis study confirms earlier data on the regulation of myelopoiesis by CD137 receptor - ligand interaction, and extends them by demonstrating the restriction of this growth promoting influence to the monocytic lineage."xsd:string |
| http://purl.uniprot.org/citations/21179444 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0015565"xsd:string |
| http://purl.uniprot.org/citations/21179444 | http://purl.uniprot.org/core/author | "Jiang D."xsd:string |
| http://purl.uniprot.org/citations/21179444 | http://purl.uniprot.org/core/author | "Schwarz H."xsd:string |
| http://purl.uniprot.org/citations/21179444 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21179444 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21179444 | http://purl.uniprot.org/core/pages | "e15565"xsd:string |
| http://purl.uniprot.org/citations/21179444 | http://purl.uniprot.org/core/title | "Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein."xsd:string |
| http://purl.uniprot.org/citations/21179444 | http://purl.uniprot.org/core/volume | "5"xsd:string |
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