| http://purl.uniprot.org/citations/21179510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21179510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21179510 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundHistidine domain-protein tyrosine phosphatase (HD-PTP) plays a key role in vesicle trafficking and biogenesis. Although it is a large protein with at least five distinct structural domains, only a few of its interactors are presently known, and the significance of these interactions is largely obscure.Methodology and resultsIn this study we performed a yeast two-hybrid screening using a human colon cDNA library and found that Grb2 and GrpL are binding partners of HD-PTP. Co-immunoprecipitation, pull-down and immunocytochemistry experiments confirmed the interactions. We also discovered that the central proline-rich and histidine-rich domain of HD-PTP is responsible for these interactions.SignificanceThe interaction of HD-PTP with two adapters of the Grb2 family, essential for numerous signaling pathways, suggests that HD-PTP might be important for signaling through a plethora of receptors."xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0014339"xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0014339"xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://purl.uniprot.org/core/author | "Tanase C.A."xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://purl.uniprot.org/core/author | "Tanase C.A."xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21179510 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21179510 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://purl.uniprot.org/core/pages | "E14339"xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://purl.uniprot.org/core/pages | "E14339"xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://purl.uniprot.org/core/title | "Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL."xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://purl.uniprot.org/core/title | "Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL."xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/21179510 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21179510 |
| http://purl.uniprot.org/citations/21179510 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21179510 |
| http://purl.uniprot.org/citations/21179510 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21179510 |
| http://purl.uniprot.org/citations/21179510 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21179510 |
| http://purl.uniprot.org/uniprot/Q9H3S7 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/21179510 |
| http://purl.uniprot.org/uniprot/O75791 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/21179510 |
| http://purl.uniprot.org/uniprot/P62993 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/21179510 |
| http://purl.uniprot.org/uniprot/O75791#attribution-5713DC4B32983188C717EB82F07FD5D3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21179510 |