| http://purl.uniprot.org/citations/21182090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21182090 | http://www.w3.org/2000/01/rdf-schema#comment | "Human Vγ9Vδ2 T cells are potent anti-tumor lymphocytes that specifically respond to pyrophosphate (phospho-) antigens, which constitute the basis of current γδ T-cell-based immunotherapy strategies. Despite a clear involvement of the TCR, the costimulation requirements of Vγ9Vδ2 T cells remain ill-defined. Here, we show that the expression of the CD27 receptor by the vast majority of Vγ9Vδ2 peripheral blood lymphocytes endows them with enhanced proliferative capacity upon ligation by its unique ligand CD70, a tumor necrosis factor superfamily member expressed on lymphoma B-cells but also on TCR-activated γδ T cells. Moreover, Vγ9Vδ2 T-cell treatment with soluble recombinant CD70 induced calcium signals and increased transcription of anti-apoptotic Bcl2a1 and cell-cycle-promoting Cyclin D2 genes. We further demonstrate that the manipulation of CD70-CD27 interactions significantly impacted on Vγ9Vδ2 T-cell survival, proliferation and cytokine secretion, in both loss-of-function and gain-of-function experiments. Thus, CD27 coreceptor signals strongly promoted the expansion of Th1-biased, CD27(+) Vγ9Vδ2 peripheral blood lymphocytes in the context of TCR-mediated stimulation with phosphoantigens. These data collectively establish a novel role for the CD70-CD27 axis in human γδ T-cell activation and hence open new perspectives for its modulation in clinical settings."xsd:string |
| http://purl.uniprot.org/citations/21182090 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201040905"xsd:string |
| http://purl.uniprot.org/citations/21182090 | http://purl.uniprot.org/core/author | "Ribot J.C."xsd:string |
| http://purl.uniprot.org/citations/21182090 | http://purl.uniprot.org/core/author | "Silva-Santos B."xsd:string |
| http://purl.uniprot.org/citations/21182090 | http://purl.uniprot.org/core/author | "Chaves-Ferreira M."xsd:string |
| http://purl.uniprot.org/citations/21182090 | http://purl.uniprot.org/core/author | "d'Orey F."xsd:string |
| http://purl.uniprot.org/citations/21182090 | http://purl.uniprot.org/core/author | "DeBarros A."xsd:string |
| http://purl.uniprot.org/citations/21182090 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21182090 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21182090 | http://purl.uniprot.org/core/pages | "195-201"xsd:string |
| http://purl.uniprot.org/citations/21182090 | http://purl.uniprot.org/core/title | "CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human gammadelta peripheral blood lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/21182090 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/21182090 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21182090 |
| http://purl.uniprot.org/citations/21182090 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21182090 |
| http://purl.uniprot.org/uniprot/#_A0A0U5JA32-mappedCitation-21182090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21182090 |
| http://purl.uniprot.org/uniprot/#_P26842-mappedCitation-21182090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21182090 |
| http://purl.uniprot.org/uniprot/#_P32970-mappedCitation-21182090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21182090 |
| http://purl.uniprot.org/uniprot/P32970 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21182090 |
| http://purl.uniprot.org/uniprot/P26842 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21182090 |
| http://purl.uniprot.org/uniprot/A0A0U5JA32 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21182090 |