| http://purl.uniprot.org/citations/21182951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21182951 | http://www.w3.org/2000/01/rdf-schema#comment | "The Neurofibromatosis type 2 tumor suppressor, schwannomin (Sch) is a plasma membrane-cytoskeleton linking protein that regulates receptor signaling and actin dynamics. We examined Sch's role in specifying morphological changes needed for Schwann cell (SC) function in vitro. Isolated Sch-GFP-expressing SCs extended bipolar processes 82% longer than those formed by GFP-expressing cells. In contrast, SCs expressing dominant negative Sch-BBA-GFP extended bipolar processes 16% shorter than controls and 64% shorter than Sch-GFP-expressing SCs. nf2 gene inactivation caused isolated mouse SCs to transition from bipolar to multipolar cells. Live imaging revealed that SCs co-expressing Sch-GFP and dominant negative RacN17 behaved similarly in dorsal root ganglion explant cultures; they quickly aligned on axons and slowly elongated bipolar processes. In contrast, SCs expressing constitutively active RacV12 underwent continuous transitions in morphology that interfered with axon alignment. When co-cultured with neurons under myelin-promoting conditions, Sch-GFP-expressing SCs elaborated longer myelin segments than GFP-expressing SCs. In contrast, Sch-BBA-GFP-expressing SCs failed to align on or myelinate axons. Together, these results demonstrate that Sch plays an essential role in inducing and/or maintaining the SC's spindle shape and suggest that the mechanism involves Sch-dependent inhibition of Rac activity. By stabilizing the bipolar morphology, Sch promotes the alignment of SCs with axons and ultimately influences myelin segment length."xsd:string |
| http://purl.uniprot.org/citations/21182951 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2010.12.006"xsd:string |
| http://purl.uniprot.org/citations/21182951 | http://purl.uniprot.org/core/author | "Bott M."xsd:string |
| http://purl.uniprot.org/citations/21182951 | http://purl.uniprot.org/core/author | "Walker B."xsd:string |
| http://purl.uniprot.org/citations/21182951 | http://purl.uniprot.org/core/author | "Lambert S."xsd:string |
| http://purl.uniprot.org/citations/21182951 | http://purl.uniprot.org/core/author | "Fernandez-Valle C."xsd:string |
| http://purl.uniprot.org/citations/21182951 | http://purl.uniprot.org/core/author | "Thaxton C."xsd:string |
| http://purl.uniprot.org/citations/21182951 | http://purl.uniprot.org/core/author | "Sparrow N.A."xsd:string |
| http://purl.uniprot.org/citations/21182951 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21182951 | http://purl.uniprot.org/core/name | "Mol Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/21182951 | http://purl.uniprot.org/core/pages | "1-9"xsd:string |
| http://purl.uniprot.org/citations/21182951 | http://purl.uniprot.org/core/title | "Schwannomin/merlin promotes Schwann cell elongation and influences myelin segment length."xsd:string |
| http://purl.uniprot.org/citations/21182951 | http://purl.uniprot.org/core/volume | "47"xsd:string |
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