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http://purl.uniprot.org/citations/21186170http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21186170http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the expression and release of HLA-G and HLA-E in JIA.

Methods

Soluble (s)HLA-G and HLA-E were measured in sera from 58 JIA patients and 54 healthy donors. Surface expression of HLA-G, HLA-E and immunoglobulin-like transcript (ILT)2 and ILT4, two receptors for HLA-G, was assessed on T, B cells and monocytes from peripheral blood (PB) and SF of 12 JIA patients and from PB of 12 controls.

Results

Serum sHLA-G concentration was significantly lower in patients than in controls. Both sHLA-G and sHLA-E were detected in SF and sHLA-E concentration in SF was higher in extended oligoarticular/polyarticular than in limited oligoarticular JIA. Patients compared with controls showed: (i) down-regulation of HLA-E and ILT2 expression on T cells; (ii) up-regulation of HLA-E expression on B cells and monocytes; and (iii) down-regulation of ILT4 expression on monocytes. Comparing JIA patients' SF and PB we found: (i) up-regulation of HLA-E and ILT2 expression in T and B cells and monocytes; and (ii) down-regulation of ILT4 expression in monocytes. ILT4 was up-regulated in monocytes from oligoarticular extended/polyarticular compared with oligoarticular limited JIA.

Conclusions

A lower concentration of sHLA-G in sera may predispose to JIA, as observed for other autoimmune diseases. sHLA-E concentration in SF correlate with the number of affected joints. Higher ILT2 expression on SF cell populations compared with PB may be related to high sHLA-G concentration in SF. Higher HLA-E expression in SF than in PB cell populations may protect them from NK cytolysis."xsd:string
http://purl.uniprot.org/citations/21186170http://purl.org/dc/terms/identifier"doi:10.1093/rheumatology/keq418"xsd:string
http://purl.uniprot.org/citations/21186170http://purl.uniprot.org/core/author"Morandi F."xsd:string
http://purl.uniprot.org/citations/21186170http://purl.uniprot.org/core/author"Gattorno M."xsd:string
http://purl.uniprot.org/citations/21186170http://purl.uniprot.org/core/author"Martini A."xsd:string
http://purl.uniprot.org/citations/21186170http://purl.uniprot.org/core/author"Pistoia V."xsd:string
http://purl.uniprot.org/citations/21186170http://purl.uniprot.org/core/author"Prigione I."xsd:string
http://purl.uniprot.org/citations/21186170http://purl.uniprot.org/core/author"Penco F."xsd:string
http://purl.uniprot.org/citations/21186170http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21186170http://purl.uniprot.org/core/name"Rheumatology (Oxford)"xsd:string
http://purl.uniprot.org/citations/21186170http://purl.uniprot.org/core/pages"966-972"xsd:string
http://purl.uniprot.org/citations/21186170http://purl.uniprot.org/core/title"HLA-G and HLA-E in patients with juvenile idiopathic arthritis."xsd:string
http://purl.uniprot.org/citations/21186170http://purl.uniprot.org/core/volume"50"xsd:string
http://purl.uniprot.org/citations/21186170http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21186170
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