| http://purl.uniprot.org/citations/21186369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21186369 | http://www.w3.org/2000/01/rdf-schema#comment | "The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases inflammation and promotes cell survival. No unifying mechanism has yet explained how adiponectin can exert such a variety of beneficial systemic effects. Here, we show that adiponectin potently stimulates a ceramidase activity associated with its two receptors, AdipoR1 and AdipoR2, and enhances ceramide catabolism and formation of its antiapoptotic metabolite--sphingosine-1-phosphate (S1P)--independently of AMP-dependent kinase (AMPK). Using models of inducible apoptosis in pancreatic beta cells and cardiomyocytes, we show that transgenic overproduction of adiponectin decreases caspase-8-mediated death, whereas genetic ablation of adiponectin enhances apoptosis in vivo through a sphingolipid-mediated pathway. Ceramidase activity is impaired in cells lacking both adiponectin receptor isoforms, leading to elevated ceramide levels and enhanced susceptibility to palmitate-induced cell death. Combined, our observations suggest a unifying mechanism of action for the beneficial systemic effects exerted by adiponectin, with sphingolipid metabolism as its core upstream signaling component."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.2277"xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Birnbaum M.J."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Holland W.L."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Miller R.A."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Scherer P.E."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Summers S.A."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Sun K."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Kuo M.S."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Zhang B.B."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Halberg N."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Wang Z.V."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Brozinick J.T."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Bui H.H."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Rutkowski J.M."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Wade M.R."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Davis K.E."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Bikman B.T."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Barth B.M."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/author | "Tenorio V.M."xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/pages | "55-63"xsd:string |
| http://purl.uniprot.org/citations/21186369 | http://purl.uniprot.org/core/title | "Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin."xsd:string |