| http://purl.uniprot.org/citations/21187433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21187433 | http://www.w3.org/2000/01/rdf-schema#comment | "Dietary absorption is a major way for mammals to obtain cholesterol, which is mediated by Niemann-Pick C1-like 1 (NPC1L1) via vesicular endocytosis. One fundamental question in this process is how free cholesterol is efficiently taken up through the internalization of NPC1L1. Using exogenously expressed NPC1L1-EGFP, we show that the lipid raft proteins flotillins associate with NPC1L1 and their localization is regulated by NPC1L1 during intracellular trafficking. Furthermore, flotillins are essential for NPC1L1-mediated cellular cholesterol uptake, biliary cholesterol reabsorption, and the regulation of lipid levels in mice. Together with NPC1L1, they form cholesterol-enriched membrane microdomains, which function as carriers for bulk of cholesterol. The hypocholesterolemic drug ezetimibe disrupts the association between NPC1L1 and flotillins, which blocks the formation of the cholesterol-enriched microdomains. Our findings reveal a functional role of flotillins in NPC1L1-mediated cholesterol uptake and elucidate the formation of NPC1L1-flotillins-postive cholesterol-enriched membrane microdomains as a mechanism for efficient cholesterol absorption."xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1014434108"xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://purl.uniprot.org/core/author | "Qi W."xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://purl.uniprot.org/core/author | "Ge L."xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://purl.uniprot.org/core/author | "Wang L.J."xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://purl.uniprot.org/core/author | "Li B.L."xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://purl.uniprot.org/core/author | "Miao H.H."xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://purl.uniprot.org/core/author | "Song B.L."xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://purl.uniprot.org/core/author | "Qu Y.X."xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21187433 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://purl.uniprot.org/core/pages | "551-556"xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://purl.uniprot.org/core/title | "Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake."xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21187433 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21187433 |
| http://purl.uniprot.org/citations/21187433 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21187433 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DGG6-mappedCitation-21187433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21187433 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JXA8-mappedCitation-21187433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21187433 |
| http://purl.uniprot.org/uniprot/#_Q14254-mappedCitation-21187433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21187433 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DFX6-mappedCitation-21187433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21187433 |
| http://purl.uniprot.org/uniprot/#_A6KT86-mappedCitation-21187433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21187433 |
| http://purl.uniprot.org/uniprot/#_A3KMG9-mappedCitation-21187433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21187433 |
| http://purl.uniprot.org/uniprot/#_A2RRR0-mappedCitation-21187433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21187433 |
| http://purl.uniprot.org/uniprot/#_A6HH00-mappedCitation-21187433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21187433 |