| http://purl.uniprot.org/citations/21189299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21189299 | http://www.w3.org/2000/01/rdf-schema#comment | "T-cell polarization is required for cell migration and cell-cell interactions, cellular behaviors crucial for lymphocyte differentiation. Despite expression of the epithelial polarity network in T cells, neither its contribution to thymocyte polarity nor its requirement during development is known. We report here that depletion of the polarity protein Scribble in hematopoietic progenitor cells results in inefficient T-cell development characterized by a partial developmental block during the early double-negative (DN) stage of differentiation. Scribble-depleted hematopoietic progenitor cells exhibit a delayed transition into late CD44(lo/-)CD25(+) DN3 cells, evidenced by the accumulation of early CD44(int)CD25(+) DN3 cells. As a consequence, a limited cellular expansion and a reduced frequency of intracellular T-cell receptor β-positive DN3 cells are observed among Scribble-deficient differentiating T cells. Moreover, whereas purified Scribble-depleted DN2 and DN3 cells do not exhibit compromised spontaneous motility, T-cell clustering and prolonged homotypic interactions among such cells are reduced. This deficiency correlates with a lack of polarization of the integrin LFA-1 during T-cell migration or on the initiation of T-cell-T-cell interactions. Scribble is therefore a critical contributor to the clustering of immature T cells, an event shown here to be necessary for efficient developmental progression."xsd:string |
| http://purl.uniprot.org/citations/21189299 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1018224108"xsd:string |
| http://purl.uniprot.org/citations/21189299 | http://purl.uniprot.org/core/author | "Pawson T."xsd:string |
| http://purl.uniprot.org/citations/21189299 | http://purl.uniprot.org/core/author | "Kulkarni S."xsd:string |
| http://purl.uniprot.org/citations/21189299 | http://purl.uniprot.org/core/author | "Pike K.A."xsd:string |
| http://purl.uniprot.org/citations/21189299 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21189299 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21189299 | http://purl.uniprot.org/core/pages | "1116-1121"xsd:string |
| http://purl.uniprot.org/citations/21189299 | http://purl.uniprot.org/core/title | "Immature T-cell clustering and efficient differentiation require the polarity protein Scribble."xsd:string |
| http://purl.uniprot.org/citations/21189299 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21189299 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21189299 |
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| http://purl.uniprot.org/uniprot/#_D3YVA3-mappedCitation-21189299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21189299 |
| http://purl.uniprot.org/uniprot/#_D3YU97-mappedCitation-21189299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21189299 |
| http://purl.uniprot.org/uniprot/#_Q6P9N3-mappedCitation-21189299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21189299 |
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| http://purl.uniprot.org/uniprot/D3YU97 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21189299 |
| http://purl.uniprot.org/uniprot/Q80U72 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21189299 |