| http://purl.uniprot.org/citations/21190939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21190939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21190939 | http://www.w3.org/2000/01/rdf-schema#comment | "The ability of interferons (IFNs) to inhibit viral replication and cellular proliferation is well established, but the specific contribution of each IFN-stimulated gene (ISG) to these biological responses remains to be completely understood. In this report we demonstrate that ISG54, also known as IFN-induced protein with tetratricopeptide repeats 2 (IFIT2), is a mediator of apoptosis. Expression of ISG54, independent of IFN stimulation, elicits apoptotic cell death. Cell death and apoptosis were quantified by propidium iodide uptake and annexin-V staining, respectively. The activation of caspase-3, a key mediator of the execution phase of apoptosis, was clearly apparent in cells expressing ISG54. The anti-apoptotic B cell lymphoma-xl (Bcl-xl) protein inhibited the apoptotic effects of ISG54 as did the anti-apoptotic adenoviral E1B-19K protein. In addition, ISG54 was not able to promote cell death in the absence of pro-apoptotic Bcl family members, Bax and Bak. Analyses of binding partners of ISG54 revealed association with two homologous proteins, ISG56/IFIT1 and ISG60/IFIT3. In addition, ISG60 binding negatively regulates the apoptotic effects of ISG54. The results reveal a previously unidentified role of ISG54 in the induction of apoptosis via a mitochondrial pathway and shed new light on the mechanism by which IFN elicits anti-viral and anti-cancer effects."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.207068"xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.207068"xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/author | "Reich N.C."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/author | "Reich N.C."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/author | "Kumar K.P."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/author | "Kumar K.P."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/author | "Stawowczyk M."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/author | "Stawowczyk M."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/author | "Van Scoy S."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/author | "Van Scoy S."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/pages | "7257-7266"xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/pages | "7257-7266"xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/title | "The interferon stimulated gene 54 promotes apoptosis."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/title | "The interferon stimulated gene 54 promotes apoptosis."xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21190939 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21190939 |
| http://purl.uniprot.org/citations/21190939 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21190939 |