| http://purl.uniprot.org/citations/21190993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21190993 | http://www.w3.org/2000/01/rdf-schema#comment | "Ecotropic viral integration site-1 (Evi-1) is a nuclear transcription factor that plays an essential role in the regulation of hematopoietic stem cells. Aberrant expression of Evi-1 has been reported in up to 10% of patients with acute myeloid leukemia and is a diagnostic marker that predicts a poor outcome. Although chromosomal rearrangement involving the Evi-1 gene is one of the major causes of Evi-1 activation, overexpression of Evi-1 is detected in a subgroup of acute myeloid leukemia patients without any chromosomal abnormalities, which indicates the presence of other mechanisms for Evi-1 activation. In this study, we found that Evi-1 is frequently up-regulated in bone marrow cells transformed by the mixed-lineage leukemia (MLL) chimeric genes MLL-ENL or MLL-AF9. Analysis of the Evi-1 gene promoter region revealed that MLL-ENL activates transcription of Evi-1. MLL-ENL-mediated up-regulation of Evi-1 occurs exclusively in the undifferentiated hematopoietic population, in which Evi-1 particularly contributes to the propagation of MLL-ENL-immortalized cells. Furthermore, gene-expression analysis of human acute myeloid leukemia cases demonstrated the stem cell-like gene-expression signature of MLL-rearranged leukemia with high levels of Evi-1. Our findings indicate that Evi-1 is one of the targets of MLL oncoproteins and is selectively activated in hematopoietic stem cell-derived MLL leukemic cells."xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-07-234310"xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/author | "Arai S."xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/author | "Ichikawa M."xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/author | "Nakagawa M."xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/author | "Yoshimi A."xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/author | "Goyama S."xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/author | "Kurokawa M."xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/author | "Shimabe M."xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/pages | "6304-6314"xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/title | "Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells."xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/21190993 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21190993 |
| http://purl.uniprot.org/citations/21190993 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21190993 |
| http://purl.uniprot.org/uniprot/#_A0A0C3SFZ7-mappedCitation-21190993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21190993 |
| http://purl.uniprot.org/uniprot/#_A0A5H1ZRN1-mappedCitation-21190993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21190993 |
| http://purl.uniprot.org/uniprot/#_H9T841-mappedCitation-21190993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21190993 |
| http://purl.uniprot.org/uniprot/#_A4QPC8-mappedCitation-21190993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21190993 |
| http://purl.uniprot.org/uniprot/#_G3UWJ0-mappedCitation-21190993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21190993 |
| http://purl.uniprot.org/uniprot/#_G3UY46-mappedCitation-21190993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21190993 |
| http://purl.uniprot.org/uniprot/#_G3UZT5-mappedCitation-21190993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21190993 |