| http://purl.uniprot.org/citations/21191074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21191074 | http://www.w3.org/2000/01/rdf-schema#comment | "Exposure to naturally occurring hydrocarbon oils is associated with the development of chronic inflammation and a wide spectrum of pathological findings in humans and animal models. The mechanism underlying the unremitting inflammatory response to hydrocarbons remains largely unclear. The medium-length alkane 2,6,10,14 tetramethylpentadecane (also known as pristane) is a hydrocarbon that potently elicits chronic peritonitis characterized by persistent infiltration of neutrophils and monocytes. In this study, we reveal the essential role of IL-1α in sustaining the chronic recruitment of neutrophils following 2,6,10,14 tetramethylpentadecane treatment. IL-1α and IL-1R signaling promote the migration of neutrophils to the peritoneal cavity in a CXCR2-dependent manner. This mechanism is at least partially dependent on the production of the neutrophil chemoattractant CXCL5. Moreover, although chronic infiltration of inflammatory monocytes is dependent on a different pathway requiring TLR-7, type I IFN receptor, and CCR2, the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)-4, IRAK-1, and IRAK-2 are shared in regulating the recruitment of both monocytes and neutrophils. Taken together, our findings uncover an IL-1α-dependent mechanism of neutrophil recruitment in hydrocarbon-induced peritonitis and illustrate the interactions of innate immune pathways in chronic inflammation."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1001328"xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/author | "Satoh M."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/author | "Lee P.Y."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/author | "Kumagai Y."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/author | "Reeves W.H."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/author | "Sobel E.S."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/author | "Barker T."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/pages | "1747-1754"xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/title | "IL-1alpha modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil."xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/21191074 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21191074 |
| http://purl.uniprot.org/citations/21191074 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21191074 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1E6-mappedCitation-21191074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21191074 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G1-mappedCitation-21191074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21191074 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-21191074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21191074 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-21191074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21191074 |