| http://purl.uniprot.org/citations/21192076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21192076 | http://www.w3.org/2000/01/rdf-schema#comment | "Since the first description of 5-HT₃ receptors more than 50 years ago, there has been speculation about the molecular basis of their receptor heterogeneity. We have cloned the genes encoding novel 5-HT3 subunits 5-HT3C, 5-HT3D, and 5-HT3E and have shown that these subunits are able to form functional heteromeric receptors when coexpressed with the 5-HT3A subunit. However, whether these subunits are actually expressed in human tissue remained to be confirmed. In the current study, we performed immunocytochemistry to locate the 5-HT3A as well as the 5-HT3C, 5-HT3D, and 5-HT3E subunits within the human colon. Western blot analysis was used to confirm subunit expression, and RT-PCR was employed to detect transcripts encoding 5-HT₃ receptor subunits in microdissected tissue samples. This investigation revealed, for the first time, that 5-HT3C, 5-HT3D, and 5-HT3E subunits are coexpressed with 5-HT3A in cell bodies of myenteric neurons. Furthermore, 5-HT3A and 5-HT3D were found to be expressed in submucosal plexus of the human large intestine. These data provide a strong basis for future studies of the roles that specific 5-HT₃ receptor subtypes play in the function of the enteric and central nervous systems and the contribution that specific 5-HT₃ receptors make to the pathophysiology of gastrointestinal disorders such as irritable bowel syndrome and dyspepsia."xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.22525"xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/author | "Gershon M.D."xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/author | "Hovius R."xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/author | "Kapeller J."xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/author | "Niesler B."xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/author | "Rappold G."xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/author | "Bruss M."xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/author | "Autschbach F."xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/author | "Lasitschka F."xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/author | "Moller D."xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/name | "J Comp Neurol"xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/pages | "420-432"xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/title | "Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E."xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://purl.uniprot.org/core/volume | "519"xsd:string |
| http://purl.uniprot.org/citations/21192076 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21192076 |
| http://purl.uniprot.org/citations/21192076 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21192076 |
| http://purl.uniprot.org/uniprot/#_A5X5Y0-mappedCitation-21192076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21192076 |
| http://purl.uniprot.org/uniprot/#_F6WC43-mappedCitation-21192076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21192076 |
| http://purl.uniprot.org/uniprot/#_Q70Z44-mappedCitation-21192076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21192076 |
| http://purl.uniprot.org/uniprot/#_Q8WXA8-mappedCitation-21192076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21192076 |
| http://purl.uniprot.org/uniprot/Q8WXA8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21192076 |
| http://purl.uniprot.org/uniprot/Q70Z44 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21192076 |