| http://purl.uniprot.org/citations/21193638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21193638 | http://www.w3.org/2000/01/rdf-schema#comment | "Munc18-1 and Syntaxin1 are essential proteins for SNARE-mediated neurotransmission. Munc18-1 participates in synaptic vesicle fusion via dual roles: as a docking/chaperone protein by binding closed Syntaxin1, and as a fusion protein that binds SNARE complexes in a Syntaxin1 N-peptide dependent manner. The two roles are associated with a closed-open Syntaxin1 conformational transition. Here, we show that Syntaxin N-peptide binding to Munc18-1 is not highly selective, suggesting that other parts of the SNARE complex are involved in binding to Munc18-1. We also find that Syntaxin1, with an N peptide and a physically anchored C terminus, binds to Munc18-1 and that this complex can participate in SNARE complex formation. We report a Munc18-1-N-peptide crystal structure that, together with other data, reveals how Munc18-1 might transit from a conformation that binds closed Syntaxin1 to one that may be compatible with binding open Syntaxin1 and SNARE complexes. Our results suggest the possibility that structural transitions occur in both Munc18-1 and Syntaxin1 during their binary interaction. We hypothesize that Munc18-1 domain 3a undergoes a conformational change that may allow coiled-coil interactions with SNARE complexes."xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0914906108"xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/author | "Collins B.M."xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/author | "Martin J.L."xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/author | "Hu S.H."xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/author | "Saez N.J."xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/author | "Lua L.H."xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/author | "Latham C.F."xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/author | "Christie M.P."xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/author | "Jarrott R."xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/pages | "1040-1045"xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/title | "Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation."xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21193638 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21193638 |
| http://purl.uniprot.org/citations/21193638 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21193638 |
| http://purl.uniprot.org/uniprot/P61765#attribution-84F8CE2DEDEAF36008822E373B5D8FF5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21193638 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2JEI5-mappedCitation-21193638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21193638 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEQ3-mappedCitation-21193638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21193638 |
| http://purl.uniprot.org/uniprot/#_D4A5W9-mappedCitation-21193638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21193638 |
| http://purl.uniprot.org/uniprot/#_P61765-mappedCitation-21193638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21193638 |
| http://purl.uniprot.org/uniprot/#_P63045-mappedCitation-21193638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21193638 |