| http://purl.uniprot.org/citations/21198750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21198750 | http://www.w3.org/2000/01/rdf-schema#comment | "Human CD26 has dipeptidyl peptidase-4 (DPP IV) enzyme activity and binds to adenosine deaminase (ADA). CD26 is costimulatory for lymphocytes and has a circulating soluble form (sCD26). DPP IV enzyme inhibition is a new successful type 2 diabetes therapy. We examined whether the ADA binding and catalytic functions of sCD26 contribute to its effects on T-cell proliferation. Wildtype soluble recombinant human CD26 (srhCD26), an enzyme inactive mutant (srhCD26E-) and an ADA non-binding mutant (srhCD26A-) were co-incubated in in vitro T-cell proliferation assays with peripheral blood mononuclear cells (PBMC) stimulated with phytohaemagglutinin (PHA), muromonab-CD3 or Herpes simplex virus antigen (HSV Ag). Both srhCD26 and srhCD26E-enhanced PHA-induced T-cell proliferation dose-dependently in all six subjects tested. srhCD26 and srhCD26A-had no overall effect on anti-CD3-stimulated PBMC proliferation in four of five subjects. srhCD26, srhCD26E- and srhCD26A-enhanced HSV Ag induced PBMC proliferation in low responders to HSV Ag, but had no effect or inhibited proliferation in HSV-high responders. Thus, effects of soluble human CD26 on human T-cell proliferation are mechanistically independent of both the enzyme activity and the ADA-binding capability of sCD26."xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-3083.2010.02488.x"xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/author | "De Meester I."xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/author | "Gorrell M.D."xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/author | "Abbott C.A."xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/author | "Gysbers V."xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/author | "McCaughan G.W."xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/author | "Yu D.M."xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/author | "Kahne T."xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/author | "Knott H.M."xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/author | "Riekhoff A.G."xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/author | "Slaitini L."xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/name | "Scand J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/pages | "102-111"xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/title | "Soluble CD26 / dipeptidyl peptidase IV enhances human lymphocyte proliferation in vitro independent of dipeptidyl peptidase enzyme activity and adenosine deaminase binding."xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/21198750 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21198750 |
| http://purl.uniprot.org/citations/21198750 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21198750 |
| http://purl.uniprot.org/uniprot/#_A0A7S4ZD15-mappedCitation-21198750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21198750 |
| http://purl.uniprot.org/uniprot/#_A0A7S4ZD17-mappedCitation-21198750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21198750 |
| http://purl.uniprot.org/uniprot/#_A0A7S4ZD76-mappedCitation-21198750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21198750 |
| http://purl.uniprot.org/uniprot/#_A0A7S4ZDQ1-mappedCitation-21198750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21198750 |
| http://purl.uniprot.org/uniprot/#_A0A7S4ZDW8-mappedCitation-21198750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21198750 |