| http://purl.uniprot.org/citations/21199872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21199872 | http://www.w3.org/2000/01/rdf-schema#comment | "The protein inhibitor of activated STAT (PIAS) family proteins regulates innate immune responses by controlling transcription induced by Toll-like receptor, RIG-I-like receptor signaling, and JAK/STAT pathways. Here, we show that PIASy negatively regulates type I interferon (IFN) transcription. Virus infection led to enhanced type I IFN induction in PIASy null cells, and conversely PIASy overexpression reduced IFN transcription. A mutation in the LXXLL motif of the SAP domain abolished inhibition of IFN-stimulated gene expression but did not affect virus or Toll-like receptor/RIG-I-like receptor-stimulated IFN transcription, indicating that PIASy employs distinct mechanisms to inhibit virus-induced and IFN-stimulated transcription. SUMO E3 activity was not required for PIASy inhibition of IFN transcription; however, PIASy relied on the SUMO modification mechanism to inhibit IFN transcription, because the activity of the SUMO-interacting motif was required for inhibition, and knockdown of SUMO E2 enzyme UBC9 decreased inhibitory activity of PIASy. Our results demonstrate that PIASy negatively regulates both IFN transcription and IFN-stimulated gene expression through multiple mechanisms utilizing the function of different domains."xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.195255"xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://purl.uniprot.org/core/author | "Kato A."xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://purl.uniprot.org/core/author | "Takeda M."xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://purl.uniprot.org/core/author | "Matsuoka M."xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://purl.uniprot.org/core/author | "Xu S."xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://purl.uniprot.org/core/author | "Kubota T."xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://purl.uniprot.org/core/author | "Otsuki N."xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://purl.uniprot.org/core/author | "Ozato K."xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21199872 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://purl.uniprot.org/core/pages | "8165-8175"xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://purl.uniprot.org/core/title | "PIASy inhibits virus-induced and interferon-stimulated transcription through distinct mechanisms."xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21199872 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21199872 |
| http://purl.uniprot.org/citations/21199872 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21199872 |
| http://purl.uniprot.org/uniprot/#_F6RKH8-mappedCitation-21199872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21199872 |
| http://purl.uniprot.org/uniprot/#_Q3V2D7-mappedCitation-21199872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21199872 |
| http://purl.uniprot.org/uniprot/#_Q3UGQ2-mappedCitation-21199872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21199872 |
| http://purl.uniprot.org/uniprot/#_Q3ULQ6-mappedCitation-21199872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21199872 |
| http://purl.uniprot.org/uniprot/#_Q9JM05-mappedCitation-21199872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21199872 |
| http://purl.uniprot.org/uniprot/F6RKH8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21199872 |
| http://purl.uniprot.org/uniprot/Q3V2D7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21199872 |
| http://purl.uniprot.org/uniprot/Q9JM05 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21199872 |