| http://purl.uniprot.org/citations/21203485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21203485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21203485 | http://www.w3.org/2000/01/rdf-schema#comment | "Epstein-Barr virus (EBV) is associated with human malignancies, especially those affecting the B cell compartment such as Burkitt lymphoma. The virally encoded homolog of the mammalian pro-survival protein Bcl-2, BHRF1 contributes to viral infectivity and lymphomagenesis. In addition to the pro-apoptotic BH3-only protein Bim, its key target in lymphoid cells, BHRF1 also binds a selective sub-set of pro-apoptotic proteins (Bid, Puma, Bak) expressed by host cells. A consequence of BHRF1 expression is marked resistance to a range of cytotoxic agents and in particular, we show that its expression renders a mouse model of Burkitt lymphoma untreatable. As current small organic antagonists of Bcl-2 do not target BHRF1, the structures of it in complex with Bim or Bak shown here will be useful to guide efforts to target BHRF1 in EBV-associated malignancies, which are usually associated with poor clinical outcomes."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1001236"xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1001236"xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Kvansakul M."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Kvansakul M."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Huang D.C."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Huang D.C."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Colman P.M."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Colman P.M."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Fletcher J.I."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Fletcher J.I."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Roberts A.W."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Roberts A.W."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Wei A.H."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Wei A.H."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Willis S.N."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/author | "Willis S.N."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/name | "PLoS Pathog."xsd:string |
| http://purl.uniprot.org/citations/21203485 | http://purl.uniprot.org/core/name | "PLoS Pathog."xsd:string |