| http://purl.uniprot.org/citations/21205795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21205795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21205795 | http://www.w3.org/2000/01/rdf-schema#comment | "The establishment of cell type-specific dendritic arborization patterns is a key phase in the assembly of neuronal circuitry that facilitates the integration and processing of synaptic and sensory input. Although studies in Drosophila and vertebrate systems have identified a variety of factors that regulate dendrite branch formation, the molecular mechanisms that control this process remain poorly defined. Here, we introduce the use of the Caenorhabditis elegans PVD neurons, a pair of putative nociceptors that elaborate complex dendritic arbors, as a tractable model for conducting high-throughput RNAi screens aimed at identifying key regulators of dendritic branch formation. By carrying out two separate RNAi screens, a small-scale candidate-based screen and a large-scale screen of the ~3000 genes on chromosome IV, we retrieved 11 genes that either promote or suppress the formation of PVD-associated dendrites. We present a detailed functional characterization of one of the genes, bicd-1, which encodes a microtubule-associated protein previously shown to modulate the transport of mRNAs and organelles in a variety of organisms. Specifically, we describe a novel role for bicd-1 in regulating dendrite branch formation and show that bicd-1 is likely to be expressed, and primarily required, in PVD neurons to control dendritic branching. We also present evidence that bicd-1 operates in a conserved pathway with dhc-1 and unc-116, components of the dynein minus-end-directed and kinesin-1 plus-end-directed microtubule-based motor complexes, respectively, and interacts genetically with the repulsive guidance receptor unc-5."xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.060939"xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.060939"xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/author | "Buelow H.E."xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/author | "Buelow H.E."xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/author | "Kaprielian Z."xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/author | "Kaprielian Z."xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/author | "Aguirre-Chen C."xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/author | "Aguirre-Chen C."xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/pages | "507-518"xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/pages | "507-518"xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/title | "C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites."xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/title | "C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites."xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/volume | "138"xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://purl.uniprot.org/core/volume | "138"xsd:string |
| http://purl.uniprot.org/citations/21205795 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21205795 |
| http://purl.uniprot.org/citations/21205795 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21205795 |
| http://purl.uniprot.org/citations/21205795 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21205795 |
| http://purl.uniprot.org/citations/21205795 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21205795 |