| http://purl.uniprot.org/citations/21209257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21209257 | http://www.w3.org/2000/01/rdf-schema#comment | "APOA5 is one of the strongest regulators of plasma TG concentrations; nevertheless, its mechanisms of action are poorly characterized. Genetic variability at the APOA5 locus has also been associated with increased cardiovascular disease risk; however, this predisposition could be attenuated in the context of a prudent diet as traditionally consumed in the Mediterranean countries. We have investigated the interaction between a single nucleotide polymorphism (SNP) at the APOA5 gene (-1131T > C) and dietary fat that may modulate TG-rich lipoprotein concentrations and anthropometric measures in overweight and obese participants. We recruited 1465 participants from a Spanish population (20-65 y old; BMI 25-40 kg/m(2)) attending outpatient obesity clinics. Consistent with previous reports, we found an association between the APOA5-1131T > C SNP and TG-rich lipoprotein concentrations that were higher in carriers of the minor allele than in noncarriers (P < 0.001). Moreover, we found a significant genotype-dietary fat interaction for obesity traits. Participants homozygous for the -1131T major allele had a positive association between fat intake and obesity, whereas in those carrying the APOA5-1131C minor allele, higher fat intakes were not associated with higher BMI. Likewise, we found genotype-dietary fat interactions for TG-rich lipoproteins (P < 0.001). In conclusion, we have replicated previous gene-diet interactions between APOA5 -1131T > C SNP and fat intake for obesity traits and detected a novel interaction for TG-rich lipoprotein concentrations. Our data support the hypothesis that the minor C-allele may protect those consuming a high-fat diet from obesity and elevated concentrations of TG-rich lipoproteins."xsd:string |
| http://purl.uniprot.org/citations/21209257 | http://purl.org/dc/terms/identifier | "doi:10.3945/jn.110.130344"xsd:string |
| http://purl.uniprot.org/citations/21209257 | http://purl.uniprot.org/core/author | "Lee Y.C."xsd:string |
| http://purl.uniprot.org/citations/21209257 | http://purl.uniprot.org/core/author | "Smith C.E."xsd:string |
| http://purl.uniprot.org/citations/21209257 | http://purl.uniprot.org/core/author | "Ordovas J.M."xsd:string |
| http://purl.uniprot.org/citations/21209257 | http://purl.uniprot.org/core/author | "Garaulet M."xsd:string |
| http://purl.uniprot.org/citations/21209257 | http://purl.uniprot.org/core/author | "Baraza J.C."xsd:string |
| http://purl.uniprot.org/citations/21209257 | http://purl.uniprot.org/core/author | "Sanchez-Moreno C."xsd:string |
| http://purl.uniprot.org/citations/21209257 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21209257 | http://purl.uniprot.org/core/name | "J Nutr"xsd:string |
| http://purl.uniprot.org/citations/21209257 | http://purl.uniprot.org/core/pages | "380-385"xsd:string |
| http://purl.uniprot.org/citations/21209257 | http://purl.uniprot.org/core/title | "APOA5 gene variation interacts with dietary fat intake to modulate obesity and circulating triglycerides in a Mediterranean population."xsd:string |
| http://purl.uniprot.org/citations/21209257 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/21209257 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21209257 |
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