| http://purl.uniprot.org/citations/21209316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21209316 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy is the major catabolic process responsible for the removal of aggregated proteins and damaged organelles. Autophagy is regulated by both G proteins and growth factors, but the underlying mechanism of how they are coordinated during initiation and reversal of autophagy is unknown. Using protein-protein interaction assays, G protein enzymology, and morphological analysis, we demonstrate here that Gα-interacting, vesicle-associated protein (GIV, a. k. a. Girdin), a nonreceptor guanine nucleotide exchange factor for Gα(i3), plays a key role in regulating autophagy and that dynamic interplay between Gα(i3), activator of G-protein signaling 3 (AGS3, its guanine nucleotide dissociation inhibitor), and GIV determines whether autophagy is promoted or inhibited. We found that AGS3 directly binds light chain 3 (LC3), recruits Gα(i3) to LC3-positive membranes upon starvation, and promotes autophagy by inhibiting the G protein. Upon growth factor stimulation, GIV disrupts the Gα(i3)-AGS3 complex, releases Gα(i3) from LC3-positive membranes, enhances anti-autophagic signaling pathways, and inhibits autophagy by activating the G protein. These results provide mechanistic insights into how reversible modulation of Gα(i3) activity by AGS3 and GIV maintains the delicate equilibrium between promotion and inhibition of autophagy."xsd:string |
| http://purl.uniprot.org/citations/21209316 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-08-0738"xsd:string |
| http://purl.uniprot.org/citations/21209316 | http://purl.uniprot.org/core/author | "Ghosh P."xsd:string |
| http://purl.uniprot.org/citations/21209316 | http://purl.uniprot.org/core/author | "Farquhar M.G."xsd:string |
| http://purl.uniprot.org/citations/21209316 | http://purl.uniprot.org/core/author | "Ear J."xsd:string |
| http://purl.uniprot.org/citations/21209316 | http://purl.uniprot.org/core/author | "Garcia-Marcos M."xsd:string |
| http://purl.uniprot.org/citations/21209316 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21209316 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/21209316 | http://purl.uniprot.org/core/pages | "673-686"xsd:string |
| http://purl.uniprot.org/citations/21209316 | http://purl.uniprot.org/core/title | "A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals."xsd:string |
| http://purl.uniprot.org/citations/21209316 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/21209316 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21209316 |
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| http://purl.uniprot.org/uniprot/#_A0A087WVF5-mappedCitation-21209316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21209316 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MSK4-mappedCitation-21209316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21209316 |
| http://purl.uniprot.org/uniprot/#_B4DSN0-mappedCitation-21209316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21209316 |
| http://purl.uniprot.org/uniprot/#_B3KW94-mappedCitation-21209316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21209316 |
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| http://purl.uniprot.org/uniprot/#_Q3V6T2-mappedCitation-21209316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21209316 |
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| http://purl.uniprot.org/uniprot/#_Q6DCA5-mappedCitation-21209316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21209316 |